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Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here we analyse genetic association data on biochemical markers of iron status from eleven European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We fi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215164/ https://www.ncbi.nlm.nih.gov/pubmed/25352340 http://dx.doi.org/10.1038/ncomms5926 |
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| author | Benyamin, Beben Esko, Tonu Ried, Janina S Radhakrishnan, Aparna Vermeulen, Sita H Traglia, Michela Gögele, Martin Anderson, Denise Broer, Linda Podmore, Clara Luan, Jian’an Kutalik, Zoltan Sanna, Serena van der Meer, Peter Tanaka, Toshiko Wang, Fudi Westra, Harm-Jan Franke, Lude Mihailov, Evelin Milani, Lili Häldin, Jonas Winkelmann, Juliane Meitinger, Thomas Thiery, Joachim Peters, Annette Waldenberger, Melanie Rendon, Augusto Jolley, Jennifer Sambrook, Jennifer Kiemeney, Lambertus A Sweep, Fred C Sala, Cinzia F Schwienbacher, Christine Pichler, Irene Hui, Jennie Demirkan, Ayse Isaacs, Aaron Amin, Najaf Steri, Maristella Waeber, Gérard Verweij, Niek Powell, Joseph E Nyholt, Dale R Heath, Andrew C Madden, Pamela AF Visscher, Peter M Wright, Margaret J Montgomery, Grant W Martin, Nicholas G Hernandez, Dena Bandinelli, Stefania van der Harst, Pim Uda, Manuela Vollenweider, Peter Scott, Robert A Langenberg, Claudia Wareham, Nicholas J van Duijn, Cornelia Beilby, John Pramstaller, Peter P Hicks, Andrew A Ouwehand, Willem H Oexle, Konrad Gieger, Christian Metspalu, Andres Camaschella, Clara Toniolo, Daniela Swinkels, Dorine W Whitfield, John B |
| author_facet | Benyamin, Beben Esko, Tonu Ried, Janina S Radhakrishnan, Aparna Vermeulen, Sita H Traglia, Michela Gögele, Martin Anderson, Denise Broer, Linda Podmore, Clara Luan, Jian’an Kutalik, Zoltan Sanna, Serena van der Meer, Peter Tanaka, Toshiko Wang, Fudi Westra, Harm-Jan Franke, Lude Mihailov, Evelin Milani, Lili Häldin, Jonas Winkelmann, Juliane Meitinger, Thomas Thiery, Joachim Peters, Annette Waldenberger, Melanie Rendon, Augusto Jolley, Jennifer Sambrook, Jennifer Kiemeney, Lambertus A Sweep, Fred C Sala, Cinzia F Schwienbacher, Christine Pichler, Irene Hui, Jennie Demirkan, Ayse Isaacs, Aaron Amin, Najaf Steri, Maristella Waeber, Gérard Verweij, Niek Powell, Joseph E Nyholt, Dale R Heath, Andrew C Madden, Pamela AF Visscher, Peter M Wright, Margaret J Montgomery, Grant W Martin, Nicholas G Hernandez, Dena Bandinelli, Stefania van der Harst, Pim Uda, Manuela Vollenweider, Peter Scott, Robert A Langenberg, Claudia Wareham, Nicholas J van Duijn, Cornelia Beilby, John Pramstaller, Peter P Hicks, Andrew A Ouwehand, Willem H Oexle, Konrad Gieger, Christian Metspalu, Andres Camaschella, Clara Toniolo, Daniela Swinkels, Dorine W Whitfield, John B |
| author_sort | Benyamin, Beben |
| collection | PubMed |
| description | Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here we analyse genetic association data on biochemical markers of iron status from eleven European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find eleven genome-wide-significant (p < 5 × 10(−8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease. |
| format | Online Article Text |
| id | pubmed-4215164 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42151642015-04-29 Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis Benyamin, Beben Esko, Tonu Ried, Janina S Radhakrishnan, Aparna Vermeulen, Sita H Traglia, Michela Gögele, Martin Anderson, Denise Broer, Linda Podmore, Clara Luan, Jian’an Kutalik, Zoltan Sanna, Serena van der Meer, Peter Tanaka, Toshiko Wang, Fudi Westra, Harm-Jan Franke, Lude Mihailov, Evelin Milani, Lili Häldin, Jonas Winkelmann, Juliane Meitinger, Thomas Thiery, Joachim Peters, Annette Waldenberger, Melanie Rendon, Augusto Jolley, Jennifer Sambrook, Jennifer Kiemeney, Lambertus A Sweep, Fred C Sala, Cinzia F Schwienbacher, Christine Pichler, Irene Hui, Jennie Demirkan, Ayse Isaacs, Aaron Amin, Najaf Steri, Maristella Waeber, Gérard Verweij, Niek Powell, Joseph E Nyholt, Dale R Heath, Andrew C Madden, Pamela AF Visscher, Peter M Wright, Margaret J Montgomery, Grant W Martin, Nicholas G Hernandez, Dena Bandinelli, Stefania van der Harst, Pim Uda, Manuela Vollenweider, Peter Scott, Robert A Langenberg, Claudia Wareham, Nicholas J van Duijn, Cornelia Beilby, John Pramstaller, Peter P Hicks, Andrew A Ouwehand, Willem H Oexle, Konrad Gieger, Christian Metspalu, Andres Camaschella, Clara Toniolo, Daniela Swinkels, Dorine W Whitfield, John B Nat Commun Article Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here we analyse genetic association data on biochemical markers of iron status from eleven European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find eleven genome-wide-significant (p < 5 × 10(−8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease. 2014-10-29 /pmc/articles/PMC4215164/ /pubmed/25352340 http://dx.doi.org/10.1038/ncomms5926 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Benyamin, Beben Esko, Tonu Ried, Janina S Radhakrishnan, Aparna Vermeulen, Sita H Traglia, Michela Gögele, Martin Anderson, Denise Broer, Linda Podmore, Clara Luan, Jian’an Kutalik, Zoltan Sanna, Serena van der Meer, Peter Tanaka, Toshiko Wang, Fudi Westra, Harm-Jan Franke, Lude Mihailov, Evelin Milani, Lili Häldin, Jonas Winkelmann, Juliane Meitinger, Thomas Thiery, Joachim Peters, Annette Waldenberger, Melanie Rendon, Augusto Jolley, Jennifer Sambrook, Jennifer Kiemeney, Lambertus A Sweep, Fred C Sala, Cinzia F Schwienbacher, Christine Pichler, Irene Hui, Jennie Demirkan, Ayse Isaacs, Aaron Amin, Najaf Steri, Maristella Waeber, Gérard Verweij, Niek Powell, Joseph E Nyholt, Dale R Heath, Andrew C Madden, Pamela AF Visscher, Peter M Wright, Margaret J Montgomery, Grant W Martin, Nicholas G Hernandez, Dena Bandinelli, Stefania van der Harst, Pim Uda, Manuela Vollenweider, Peter Scott, Robert A Langenberg, Claudia Wareham, Nicholas J van Duijn, Cornelia Beilby, John Pramstaller, Peter P Hicks, Andrew A Ouwehand, Willem H Oexle, Konrad Gieger, Christian Metspalu, Andres Camaschella, Clara Toniolo, Daniela Swinkels, Dorine W Whitfield, John B Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title | Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title_full | Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title_fullStr | Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title_full_unstemmed | Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title_short | Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| title_sort | novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215164/ https://www.ncbi.nlm.nih.gov/pubmed/25352340 http://dx.doi.org/10.1038/ncomms5926 |
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