lncRNA and gene looping: what’s the connection?

Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the players involved in chromatin organization, including lncR...

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Detalles Bibliográficos
Autores principales: Shibayama, Youtaro, Fanucchi, Stephanie, Magagula, Loretta, Mhlanga, Musa M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215167/
https://www.ncbi.nlm.nih.gov/pubmed/25764331
http://dx.doi.org/10.4161/trns.28658
Descripción
Sumario:Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the players involved in chromatin organization, including lncRNA, is emerging.

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