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Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes

The initial step in initiation of eukaryotic DNA replication involves the assembly of pre-replicative complexes (pre-RCs) at origins of replication during the G(1) phase of the cell cycle. In metazoans initiation is inhibited by the regulatory factor Geminin. We have purified the human pre-RC protei...

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Detalles Bibliográficos
Autores principales:	Wu, Min, Lu, Wenyan, Santos, Ruth E., Frattini, Mark G., Kelly, Thomas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215257/ https://www.ncbi.nlm.nih.gov/pubmed/25231993 http://dx.doi.org/10.1074/jbc.M114.552935

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