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Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays

Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis...

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Autores principales: Won, Ha-Kyeong, Lee, Ji-Won, Song, Woo-Jung, Klaewsongkram, Jettanong, Kang, Min-Gyu, Park, Han-Ki, Lee, Hyun-Seung, Kim, Min-Hye, Chang, Yoon-Seok, Cho, Sang-Heon, Min, Kyung-Up
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215432/
https://www.ncbi.nlm.nih.gov/pubmed/25379485
http://dx.doi.org/10.5415/apallergy.2014.4.4.253
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author Won, Ha-Kyeong
Lee, Ji-Won
Song, Woo-Jung
Klaewsongkram, Jettanong
Kang, Min-Gyu
Park, Han-Ki
Lee, Hyun-Seung
Kim, Min-Hye
Chang, Yoon-Seok
Cho, Sang-Heon
Min, Kyung-Up
author_facet Won, Ha-Kyeong
Lee, Ji-Won
Song, Woo-Jung
Klaewsongkram, Jettanong
Kang, Min-Gyu
Park, Han-Ki
Lee, Hyun-Seung
Kim, Min-Hye
Chang, Yoon-Seok
Cho, Sang-Heon
Min, Kyung-Up
author_sort Won, Ha-Kyeong
collection PubMed
description Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays.
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spelling pubmed-42154322014-11-06 Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays Won, Ha-Kyeong Lee, Ji-Won Song, Woo-Jung Klaewsongkram, Jettanong Kang, Min-Gyu Park, Han-Ki Lee, Hyun-Seung Kim, Min-Hye Chang, Yoon-Seok Cho, Sang-Heon Min, Kyung-Up Asia Pac Allergy Case Report Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014-10 2014-10-29 /pmc/articles/PMC4215432/ /pubmed/25379485 http://dx.doi.org/10.5415/apallergy.2014.4.4.253 Text en Copyright © 2014. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Won, Ha-Kyeong
Lee, Ji-Won
Song, Woo-Jung
Klaewsongkram, Jettanong
Kang, Min-Gyu
Park, Han-Ki
Lee, Hyun-Seung
Kim, Min-Hye
Chang, Yoon-Seok
Cho, Sang-Heon
Min, Kyung-Up
Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title_full Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title_fullStr Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title_full_unstemmed Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title_short Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
title_sort lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215432/
https://www.ncbi.nlm.nih.gov/pubmed/25379485
http://dx.doi.org/10.5415/apallergy.2014.4.4.253
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