Cargando…

Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study

BACKGROUND/AIMS: Superficial esophageal squamous cell carcinoma (SESCC) is being increasingly detected during screening endoscopy. Endoscopic submucosal dissection (ESD) allows for en bloc and histologically complete resection of lesions. This study assessed the technical feasibility and long-term o...

Descripción completa

Detalles Bibliográficos
Autores principales: Joo, Dong Chan, Kim, Gwang Ha, Park, Do Youn, Jhi, Joon Hyung, Song, Geun Am
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Gut and Liver 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215446/
https://www.ncbi.nlm.nih.gov/pubmed/25368748
http://dx.doi.org/10.5009/gnl13130
_version_ 1782342096511827968
author Joo, Dong Chan
Kim, Gwang Ha
Park, Do Youn
Jhi, Joon Hyung
Song, Geun Am
author_facet Joo, Dong Chan
Kim, Gwang Ha
Park, Do Youn
Jhi, Joon Hyung
Song, Geun Am
author_sort Joo, Dong Chan
collection PubMed
description BACKGROUND/AIMS: Superficial esophageal squamous cell carcinoma (SESCC) is being increasingly detected during screening endoscopy. Endoscopic submucosal dissection (ESD) allows for en bloc and histologically complete resection of lesions. This study assessed the technical feasibility and long-term outcomes of ESD for SESCCs. METHODS: Between January 2005 and August 2012, 27 patients with 28 SESCCs underwent ESD at Pusan National University Hospital. The en bloc and pathologically complete resection rates, complication (perforation and bleeding) rate, incidence of esophageal stricture after ESD, and overall and disease-specific survival rates were evaluated. RESULTS: The en bloc and pathologically complete resection rates were 93% and 83%, respectively. No significant bleeding occurred, and perforation with mediastinal emphysema was observed in two patients (7%). Post-ESD stricture occurred in two patients (7%) who had mucosal defects involving more than three-fourths of the esophageal circumference. During a mean follow-up of 23 months, local tumor recurrence was seen in two of four lesions with pathologically incomplete resection; one was treated by re-ESD, and the other was treated by surgical esophagectomy. The 5-year overall and disease-specific survival rates were 84% and 100%, respectively. CONCLUSIONS: ESD seems to be a feasible, effective curative treatment for SESCCs. All patients should be closely followed after ESD.
format Online
Article
Text
id pubmed-4215446
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Gut and Liver
record_format MEDLINE/PubMed
spelling pubmed-42154462014-11-03 Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study Joo, Dong Chan Kim, Gwang Ha Park, Do Youn Jhi, Joon Hyung Song, Geun Am Gut Liver Original Article BACKGROUND/AIMS: Superficial esophageal squamous cell carcinoma (SESCC) is being increasingly detected during screening endoscopy. Endoscopic submucosal dissection (ESD) allows for en bloc and histologically complete resection of lesions. This study assessed the technical feasibility and long-term outcomes of ESD for SESCCs. METHODS: Between January 2005 and August 2012, 27 patients with 28 SESCCs underwent ESD at Pusan National University Hospital. The en bloc and pathologically complete resection rates, complication (perforation and bleeding) rate, incidence of esophageal stricture after ESD, and overall and disease-specific survival rates were evaluated. RESULTS: The en bloc and pathologically complete resection rates were 93% and 83%, respectively. No significant bleeding occurred, and perforation with mediastinal emphysema was observed in two patients (7%). Post-ESD stricture occurred in two patients (7%) who had mucosal defects involving more than three-fourths of the esophageal circumference. During a mean follow-up of 23 months, local tumor recurrence was seen in two of four lesions with pathologically incomplete resection; one was treated by re-ESD, and the other was treated by surgical esophagectomy. The 5-year overall and disease-specific survival rates were 84% and 100%, respectively. CONCLUSIONS: ESD seems to be a feasible, effective curative treatment for SESCCs. All patients should be closely followed after ESD. Gut and Liver 2014-11 2014-11-01 /pmc/articles/PMC4215446/ /pubmed/25368748 http://dx.doi.org/10.5009/gnl13130 Text en Copyright © 2014 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Joo, Dong Chan
Kim, Gwang Ha
Park, Do Youn
Jhi, Joon Hyung
Song, Geun Am
Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title_full Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title_fullStr Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title_full_unstemmed Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title_short Long-Term Outcome after Endoscopic Submucosal Dissection in Patients with Superficial Esophageal Squamous Cell Carcinoma: A Single-Center Study
title_sort long-term outcome after endoscopic submucosal dissection in patients with superficial esophageal squamous cell carcinoma: a single-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215446/
https://www.ncbi.nlm.nih.gov/pubmed/25368748
http://dx.doi.org/10.5009/gnl13130
work_keys_str_mv AT joodongchan longtermoutcomeafterendoscopicsubmucosaldissectioninpatientswithsuperficialesophagealsquamouscellcarcinomaasinglecenterstudy
AT kimgwangha longtermoutcomeafterendoscopicsubmucosaldissectioninpatientswithsuperficialesophagealsquamouscellcarcinomaasinglecenterstudy
AT parkdoyoun longtermoutcomeafterendoscopicsubmucosaldissectioninpatientswithsuperficialesophagealsquamouscellcarcinomaasinglecenterstudy
AT jhijoonhyung longtermoutcomeafterendoscopicsubmucosaldissectioninpatientswithsuperficialesophagealsquamouscellcarcinomaasinglecenterstudy
AT songgeunam longtermoutcomeafterendoscopicsubmucosaldissectioninpatientswithsuperficialesophagealsquamouscellcarcinomaasinglecenterstudy