Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polym...

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Detalles Bibliográficos
Autores principales: Hegedűs, Csaba, Virág, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215470/
https://www.ncbi.nlm.nih.gov/pubmed/25460733
http://dx.doi.org/10.1016/j.redox.2014.08.003
Descripción
Sumario:Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme.

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