Cargando…

Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain

A series of studies have consistently reproduced left neglect-like bias on line length estimation tasks in healthy participants by applying transcranial magnetic stimulation (TMS) over the right posterior parietal cortex (PPC), while no significant changes have been reported when stimulating the lef...

Descripción completa

Detalles Bibliográficos
Autores principales: Salatino, Adriana, Poncini, Marisa, George, Mark S., Ricci, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215615/
https://www.ncbi.nlm.nih.gov/pubmed/25400612
http://dx.doi.org/10.3389/fpsyg.2014.01238
_version_ 1782342127409168384
author Salatino, Adriana
Poncini, Marisa
George, Mark S.
Ricci, Raffaella
author_facet Salatino, Adriana
Poncini, Marisa
George, Mark S.
Ricci, Raffaella
author_sort Salatino, Adriana
collection PubMed
description A series of studies have consistently reproduced left neglect-like bias on line length estimation tasks in healthy participants by applying transcranial magnetic stimulation (TMS) over the right posterior parietal cortex (PPC), while no significant changes have been reported when stimulating the left PPC. However, a notable inter-individual variability in the right parietal site where TMS modulates visuospatial perception can be observed, and no general agreement exists on how to identify the optimal parietal site of stimulation. In the present study, we propose a new site-finding TMS protocol to easily identify the optimum parietal location, or “hot spot,” where TMS may modulate visuospatial perception on a line length estimation task (the Landmark task). Single-pulse TMS at 115% of motor threshold was applied 150 ms after the visual stimulus onset over nine different sites of a 3 cm × 3 cm grid, centred over right or left PPC (P4 and P3 according to the 10–20 EEG system, respectively) in eight healthy participants. Stimulation of right PPC induced a significant left neglect-like bias, when the coil was applied over the most posterior and dorso-posterior sites. Unexpectedly, TMS over left PPC also produced left neglect-like bias. However, in this case significant effects were found when targeting the most anterior and dorso-anterior portions of the grid. These results are discussed in relation to recent findings on neural networks underlying spatial cognition. The hunting protocol we propose might offer an economical and easy-to-use tool to functionally identify the optimal parietal site where TMS can modulate visuospatial perception, in healthy subjects and possibly in post-stroke patients undergoing repetitive transcranial magnetic stimulation treatment.
format Online
Article
Text
id pubmed-4215615
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-42156152014-11-14 Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain Salatino, Adriana Poncini, Marisa George, Mark S. Ricci, Raffaella Front Psychol Psychology A series of studies have consistently reproduced left neglect-like bias on line length estimation tasks in healthy participants by applying transcranial magnetic stimulation (TMS) over the right posterior parietal cortex (PPC), while no significant changes have been reported when stimulating the left PPC. However, a notable inter-individual variability in the right parietal site where TMS modulates visuospatial perception can be observed, and no general agreement exists on how to identify the optimal parietal site of stimulation. In the present study, we propose a new site-finding TMS protocol to easily identify the optimum parietal location, or “hot spot,” where TMS may modulate visuospatial perception on a line length estimation task (the Landmark task). Single-pulse TMS at 115% of motor threshold was applied 150 ms after the visual stimulus onset over nine different sites of a 3 cm × 3 cm grid, centred over right or left PPC (P4 and P3 according to the 10–20 EEG system, respectively) in eight healthy participants. Stimulation of right PPC induced a significant left neglect-like bias, when the coil was applied over the most posterior and dorso-posterior sites. Unexpectedly, TMS over left PPC also produced left neglect-like bias. However, in this case significant effects were found when targeting the most anterior and dorso-anterior portions of the grid. These results are discussed in relation to recent findings on neural networks underlying spatial cognition. The hunting protocol we propose might offer an economical and easy-to-use tool to functionally identify the optimal parietal site where TMS can modulate visuospatial perception, in healthy subjects and possibly in post-stroke patients undergoing repetitive transcranial magnetic stimulation treatment. Frontiers Media S.A. 2014-10-31 /pmc/articles/PMC4215615/ /pubmed/25400612 http://dx.doi.org/10.3389/fpsyg.2014.01238 Text en Copyright © 2014 Salatino, Poncini, George and Ricci. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Salatino, Adriana
Poncini, Marisa
George, Mark S.
Ricci, Raffaella
Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title_full Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title_fullStr Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title_full_unstemmed Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title_short Hunting for right and left parietal hot spots using single-pulse TMS: modulation of visuospatial perception during line bisection judgment in the healthy brain
title_sort hunting for right and left parietal hot spots using single-pulse tms: modulation of visuospatial perception during line bisection judgment in the healthy brain
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215615/
https://www.ncbi.nlm.nih.gov/pubmed/25400612
http://dx.doi.org/10.3389/fpsyg.2014.01238
work_keys_str_mv AT salatinoadriana huntingforrightandleftparietalhotspotsusingsinglepulsetmsmodulationofvisuospatialperceptionduringlinebisectionjudgmentinthehealthybrain
AT poncinimarisa huntingforrightandleftparietalhotspotsusingsinglepulsetmsmodulationofvisuospatialperceptionduringlinebisectionjudgmentinthehealthybrain
AT georgemarks huntingforrightandleftparietalhotspotsusingsinglepulsetmsmodulationofvisuospatialperceptionduringlinebisectionjudgmentinthehealthybrain
AT ricciraffaella huntingforrightandleftparietalhotspotsusingsinglepulsetmsmodulationofvisuospatialperceptionduringlinebisectionjudgmentinthehealthybrain