Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression

Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here, we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumor...

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Detalles Bibliográficos
Autores principales: Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A, Zhang, Wei, Lopez-Berestein, Gabriel, Sood, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215647/
https://www.ncbi.nlm.nih.gov/pubmed/25351346
http://dx.doi.org/10.1038/ncomms6202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215647/
https://www.ncbi.nlm.nih.gov/pubmed/25351346
http://dx.doi.org/10.1038/ncomms6202

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