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Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

The Polycomb group of epigenetic enzymes represses expression of developmentally regulated genes in higher eukaryotes. This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys119 using its E3 ubiquitin ligase subunits, Ring1B and Bmi1, together wi...

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Detalles Bibliográficos
Autores principales:	McGinty, Robert K., Henrici, Ryan C., Tan, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215650/ https://www.ncbi.nlm.nih.gov/pubmed/25355358 http://dx.doi.org/10.1038/nature13890

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