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Reappraisal of glucocorticoids in castrate-resistant prostate cancer

Recent reports and discussions of preclinical prostate cancer models have emphasized the possibility that enzalutamide resistance may be mediated by glucocorticoid receptors (GR).12 In both in vitro and xenograft animal studies, it is possible to show that the GR is up-regulated in prostate cancer c...

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Detalles Bibliográficos
Autores principales: Sartor, Oliver, Parker, Christopher C, de Bono, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215665/
https://www.ncbi.nlm.nih.gov/pubmed/24994787
http://dx.doi.org/10.4103/1008-682X.133314
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author Sartor, Oliver
Parker, Christopher C
de Bono, Johann
author_facet Sartor, Oliver
Parker, Christopher C
de Bono, Johann
author_sort Sartor, Oliver
collection PubMed
description Recent reports and discussions of preclinical prostate cancer models have emphasized the possibility that enzalutamide resistance may be mediated by glucocorticoid receptors (GR).12 In both in vitro and xenograft animal studies, it is possible to show that the GR is up-regulated in prostate cancer cell lines and that dexamethasone reverses enzalutamide induced growth inhibition. In these model systems, GR agonists can induce a subset of androgen receptor target genes including prostate-specific antigen. These investigators also report a correlation between GR expression in patient-derived prostate cancer specimens and clinical response to enzalutamide. The authors discuss the possibility that these findings have important clinical relevance. We note that the current clinical evidence for GR mediating drug resistance or disease progression in patients with castrate-resistant prostate cancer (CRPC) is very limited at best.
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spelling pubmed-42156652014-11-04 Reappraisal of glucocorticoids in castrate-resistant prostate cancer Sartor, Oliver Parker, Christopher C de Bono, Johann Asian J Androl Invited Research Highlight Recent reports and discussions of preclinical prostate cancer models have emphasized the possibility that enzalutamide resistance may be mediated by glucocorticoid receptors (GR).12 In both in vitro and xenograft animal studies, it is possible to show that the GR is up-regulated in prostate cancer cell lines and that dexamethasone reverses enzalutamide induced growth inhibition. In these model systems, GR agonists can induce a subset of androgen receptor target genes including prostate-specific antigen. These investigators also report a correlation between GR expression in patient-derived prostate cancer specimens and clinical response to enzalutamide. The authors discuss the possibility that these findings have important clinical relevance. We note that the current clinical evidence for GR mediating drug resistance or disease progression in patients with castrate-resistant prostate cancer (CRPC) is very limited at best. Medknow Publications & Media Pvt Ltd 2014 2014-06-24 /pmc/articles/PMC4215665/ /pubmed/24994787 http://dx.doi.org/10.4103/1008-682X.133314 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Research Highlight
Sartor, Oliver
Parker, Christopher C
de Bono, Johann
Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title_full Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title_fullStr Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title_full_unstemmed Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title_short Reappraisal of glucocorticoids in castrate-resistant prostate cancer
title_sort reappraisal of glucocorticoids in castrate-resistant prostate cancer
topic Invited Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215665/
https://www.ncbi.nlm.nih.gov/pubmed/24994787
http://dx.doi.org/10.4103/1008-682X.133314
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