Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives

Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a...

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Detalles Bibliográficos
Autores principales: Kläver, Ruth, Gromoll, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215682/
https://www.ncbi.nlm.nih.gov/pubmed/24923457
http://dx.doi.org/10.4103/1008-682X.125412
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author Kläver, Ruth
Gromoll, Jörg
author_facet Kläver, Ruth
Gromoll, Jörg
author_sort Kläver, Ruth
collection PubMed
description Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described.
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spelling pubmed-42156822014-11-04 Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives Kläver, Ruth Gromoll, Jörg Asian J Androl Perspective Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described. Medknow Publications & Media Pvt Ltd 2014 2014-05-30 /pmc/articles/PMC4215682/ /pubmed/24923457 http://dx.doi.org/10.4103/1008-682X.125412 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Kläver, Ruth
Gromoll, Jörg
Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title_full Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title_fullStr Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title_full_unstemmed Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title_short Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
title_sort bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215682/
https://www.ncbi.nlm.nih.gov/pubmed/24923457
http://dx.doi.org/10.4103/1008-682X.125412
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