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Muscle stem cells at a glance

Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, th...

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Detalles Bibliográficos
Autores principales: Wang, Yu Xin, Dumont, Nicolas A., Rudnicki, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215708/
https://www.ncbi.nlm.nih.gov/pubmed/25300792
http://dx.doi.org/10.1242/jcs.151209
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author Wang, Yu Xin
Dumont, Nicolas A.
Rudnicki, Michael A.
author_facet Wang, Yu Xin
Dumont, Nicolas A.
Rudnicki, Michael A.
author_sort Wang, Yu Xin
collection PubMed
description Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar to other adult stem cells, understanding the molecular regulation of muscle stem cells has significant implications towards the development of pharmacological or cell-based therapies for muscle disorders. This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment.
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spelling pubmed-42157082014-11-17 Muscle stem cells at a glance Wang, Yu Xin Dumont, Nicolas A. Rudnicki, Michael A. J Cell Sci Cell Science at a Glance Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar to other adult stem cells, understanding the molecular regulation of muscle stem cells has significant implications towards the development of pharmacological or cell-based therapies for muscle disorders. This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment. The Company of Biologists 2014-11-01 /pmc/articles/PMC4215708/ /pubmed/25300792 http://dx.doi.org/10.1242/jcs.151209 Text en © 2014. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Cell Science at a Glance
Wang, Yu Xin
Dumont, Nicolas A.
Rudnicki, Michael A.
Muscle stem cells at a glance
title Muscle stem cells at a glance
title_full Muscle stem cells at a glance
title_fullStr Muscle stem cells at a glance
title_full_unstemmed Muscle stem cells at a glance
title_short Muscle stem cells at a glance
title_sort muscle stem cells at a glance
topic Cell Science at a Glance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215708/
https://www.ncbi.nlm.nih.gov/pubmed/25300792
http://dx.doi.org/10.1242/jcs.151209
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