Cargando…

Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia

The pursuit of targeting multiple pathways in the ischemic cascade of cerebral stroke is a promising treatment option. We examined the regenerative potential of conditioned medium derived from rat and human apoptotic mononuclear cells (MNC), rMNC (apo sec) and hMNC (apo sec), in experimental stroke....

Descripción completa

Detalles Bibliográficos
Autores principales:	Altmann, Patrick, Mildner, Michael, Haider, Thomas, Traxler, Denise, Beer, Lucian, Ristl, Robin, Golabi, Bahar, Gabriel, Christian, Leutmezer, Fritz, Ankersmit, Hendrik Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215751/ https://www.ncbi.nlm.nih.gov/pubmed/25383184 http://dx.doi.org/10.12688/f1000research.4219.2

Ejemplares similares

Peripheral blood mononuclear cell secretome for tissue repair
por: Beer, Lucian, et al.
Publicado: (2016)

Secretome of Peripheral Blood Mononuclear Cells Enhances Wound Healing
por: Mildner, Michael, et al.
Publicado: (2013)

The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
por: Vorstandlechner, Vera, et al.
Publicado: (2023)

Dying blood mononuclear cell secretome exerts antimicrobial activity
por: Kasiri, Mohammad Mahdi, et al.
Publicado: (2016)

Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration
por: Beer, Lucian, et al.
Publicado: (2015)

The secretome of stressed peripheral blood mononuclear cells increases tissue survival in a rodent epigastric flap model
por: Hacker, Stefan, et al.
Publicado: (2020)

Ionizing radiation regulates long non-coding RNAs in human peripheral blood mononuclear cells
por: Beer, Lucian, et al.
Publicado: (2017)

TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis
por: Panahipour, Layla, et al.
Publicado: (2020)

Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I)
por: Simader, Elisabeth, et al.
Publicado: (2017)

Tissue-regenerative potential of the secretome of γ-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis
por: Simader, Elisabeth, et al.
Publicado: (2019)

Mononuclear cell secretome protects from experimental autoimmune myocarditis
por: Hoetzenecker, Konrad, et al.
Publicado: (2015)

High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells
por: Beer, Lucian, et al.
Publicado: (2014)

Secretome of Stressed Peripheral Blood Mononuclear Cells Alters Transcriptome Signature in Heart, Liver, and Spleen after an Experimental Acute Myocardial Infarction: An In Silico Analysis
por: Mildner, Caterina Selina, et al.
Publicado: (2022)

The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils
por: Laggner, Maria, et al.
Publicado: (2022)

Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction
por: Lichtenauer, Michael, et al.
Publicado: (2011)

Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia
por: Zimmermann, Matthias, et al.
Publicado: (2017)

Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions
por: Wagner, Tanja, et al.
Publicado: (2018)

Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
por: Wuschko, Silvio, et al.
Publicado: (2019)

Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study
por: Lichtenauer, Michael, et al.
Publicado: (2011)

Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
por: Laggner, Maria, et al.
Publicado: (2020)

Role for Lipids Secreted by Irradiated Peripheral Blood Mononuclear Cells in Inflammatory Resolution in Vitro
por: Panahipour, Layla, et al.
Publicado: (2020)

Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model
por: Hacker, Stefan, et al.
Publicado: (2016)

Safety and clinical efficacy of the secretome of stressed peripheral blood mononuclear cells in patients with diabetic foot ulcer—study protocol of the randomized, placebo-controlled, double-blind, multicenter, international phase II clinical trial MARSYAS II
por: Gugerell, Alfred, et al.
Publicado: (2021)

Abstract: 10.40 Paracrine Factors From Human Peripheral Blood Mononuclear Cells Improve Wound Healing, Scar Quality, And Angiogenesis In A Porcine Burn Model
por: Hacker, Stefan, et al.
Publicado: (2017)

Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
por: Hoetzenecker, K., et al.
Publicado: (2012)

Paracrine Factors of Stressed Peripheral Blood Mononuclear Cells Activate Proangiogenic and Anti-Proteolytic Processes in Whole Blood Cells and Protect the Endothelial Barrier
por: Copic, Dragan, et al.
Publicado: (2022)

The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
por: Vorstandlechner, Vera, et al.
Publicado: (2021)

The Effect of Paracrine Factors Released by Irradiated Peripheral Blood Mononuclear Cells on Neutrophil Extracellular Trap Formation
por: Klas, Katharina, et al.
Publicado: (2022)

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary Hypertension
por: Laggner, Maria, et al.
Publicado: (2022)

Intravenous administration of DPSCs and BDNF improves neurological performance in rats with focal cerebral ischemia
por: Zhang, Xuemei, et al.
Publicado: (2018)

Secretome as a Tool to Treat Neurological Conditions: Are We Ready?
por: da Silva, Andreia Valente, et al.
Publicado: (2023)

Mechanical aortic valve prostheses offer a survival benefit in 50–65 year olds: AUTHEARTVISIT study
por: Traxler, Denise, et al.
Publicado: (2021)

Comparison of the anti-apoptotic effects of 15- and 35-minute suspended moxibustion after focal cerebral ischemia/reperfusion injury
por: Xiao, Ai-jiao, et al.
Publicado: (2018)

Gualou Guizhi decoction promotes neurological functional recovery and neurogenesis following focal cerebral ischemia/reperfusion
por: Han, Jing, et al.
Publicado: (2018)

Ginseng-Angelica-Sansheng-Pulvis Boosts Neurogenesis Against Focal Cerebral Ischemia-Induced Neurological Deficiency
por: Liu, Bowen, et al.
Publicado: (2019)

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep
por: Härtig, Wolfgang, et al.
Publicado: (2017)

Effect of bone marrow stromal cell transplantation on neurologic function and expression of VEGF in rats with focal cerebral ischemia
por: LI, NAN, et al.
Publicado: (2014)

Treatment with Nasal Neuro-EPO Improves the Neurological, Cognitive, and Histological State in a Gerbil Model of Focal Ischemia
por: Rodríguez Cruz, Yamila, et al.
Publicado: (2010)

Animal models of focal brain ischemia
por: Sicard, Kenneth M, et al.
Publicado: (2009)

Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases
por: Schweiger, Thomas, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i9jkdtdb43qji63aq0uc4i3rib