Role of the Fast Kinetics of Pyroglutamate-Modified Amyloid-β Oligomers in Membrane Binding and Membrane Permeability

[Image: see text] Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer’s disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental role in the processes leadi...

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Detalles Bibliográficos
Autores principales: Lee, Joon, Gillman, Alan L., Jang, Hyunbum, Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Teran Arce, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215883/
https://www.ncbi.nlm.nih.gov/pubmed/24950761
http://dx.doi.org/10.1021/bi500587p

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