Cutaneous Epithelial Tumors Induced by Vemurafenib Involve the MAPK and Pi3KCA Pathways but Not HPV nor HPyV Viral Infection

The inhibitors of mutant BRAF that are used to treat metastatic melanoma induce squamoproliferative lesions. We conducted a prospective histopathological and molecular study on 27 skin lesions from 12 patients treated with vemurafenib. Mutation hot spots in HRAS, NRAS, KRAS, BRAF, and Pi3KCA were sc...

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Detalles Bibliográficos
Autores principales: Frouin, Eric, Guillot, Bernard, Larrieux, Marion, Tempier, Ariane, Boulle, Nathalie, Foulongne, Vincent, Girard, Céline, Costes, Valérie, Solassol, Jérome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215900/
https://www.ncbi.nlm.nih.gov/pubmed/25360634
http://dx.doi.org/10.1371/journal.pone.0110478

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