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Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor

OBJECTIVE: Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1 (CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma, but the significance...

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Autores principales: Sato, Naoko, Takagi, Kiyoshi, Suzuki, Takashi, Miki, Yasuhiro, Tanaka, Sota, Nagase, Satoru, Warita, Hitoshi, Fukudo, Shin, Sato, Fumiko, Sasano, Hironobu, Ito, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215916/
https://www.ncbi.nlm.nih.gov/pubmed/25254562
http://dx.doi.org/10.1097/IGC.0000000000000269
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author Sato, Naoko
Takagi, Kiyoshi
Suzuki, Takashi
Miki, Yasuhiro
Tanaka, Sota
Nagase, Satoru
Warita, Hitoshi
Fukudo, Shin
Sato, Fumiko
Sasano, Hironobu
Ito, Kiyoshi
author_facet Sato, Naoko
Takagi, Kiyoshi
Suzuki, Takashi
Miki, Yasuhiro
Tanaka, Sota
Nagase, Satoru
Warita, Hitoshi
Fukudo, Shin
Sato, Fumiko
Sasano, Hironobu
Ito, Kiyoshi
author_sort Sato, Naoko
collection PubMed
description OBJECTIVE: Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1 (CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma, but the significance of these proteins has remained largely unknown in human endometrial carcinoma. MATERIALS AND METHODS: A total of 87 endometrial carcinoma specimens were obtained from Japanese female patients who underwent surgical treatment, fixed in 10% formalin, and embedded in paraffin wax. Immunohistochemistry for CRH, CRHR1, and CRHR2 was performed, and clinical data were obtained from the medical records. RESULTS: Immunopositivity of CRH, CRHR1, and CRHR2 in the specimens was 26%, 15%, and 10%, respectively. Univariate analysis revealed that immunohistochemical CRH status was positively associated with CRHR1 and CRHR2 status and that CRHR1 status was significantly associated with the risk of recurrence and poorer clinical outcome, whereas CRHR2 status was marginally associated with better prognosis for overall survival. Multivariate analysis demonstrated CRHR1 status as an independent prognostic factor for both disease-free and overall survival. CONCLUSIONS: These results suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease.
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spelling pubmed-42159162014-11-03 Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor Sato, Naoko Takagi, Kiyoshi Suzuki, Takashi Miki, Yasuhiro Tanaka, Sota Nagase, Satoru Warita, Hitoshi Fukudo, Shin Sato, Fumiko Sasano, Hironobu Ito, Kiyoshi Int J Gynecol Cancer Basic Science OBJECTIVE: Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1 (CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma, but the significance of these proteins has remained largely unknown in human endometrial carcinoma. MATERIALS AND METHODS: A total of 87 endometrial carcinoma specimens were obtained from Japanese female patients who underwent surgical treatment, fixed in 10% formalin, and embedded in paraffin wax. Immunohistochemistry for CRH, CRHR1, and CRHR2 was performed, and clinical data were obtained from the medical records. RESULTS: Immunopositivity of CRH, CRHR1, and CRHR2 in the specimens was 26%, 15%, and 10%, respectively. Univariate analysis revealed that immunohistochemical CRH status was positively associated with CRHR1 and CRHR2 status and that CRHR1 status was significantly associated with the risk of recurrence and poorer clinical outcome, whereas CRHR2 status was marginally associated with better prognosis for overall survival. Multivariate analysis demonstrated CRHR1 status as an independent prognostic factor for both disease-free and overall survival. CONCLUSIONS: These results suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease. Lippincott Williams & Wilkins 2014-11 2014-10-24 /pmc/articles/PMC4215916/ /pubmed/25254562 http://dx.doi.org/10.1097/IGC.0000000000000269 Text en Copyright © 2014 by IGCS and ESGO This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Basic Science
Sato, Naoko
Takagi, Kiyoshi
Suzuki, Takashi
Miki, Yasuhiro
Tanaka, Sota
Nagase, Satoru
Warita, Hitoshi
Fukudo, Shin
Sato, Fumiko
Sasano, Hironobu
Ito, Kiyoshi
Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title_full Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title_fullStr Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title_full_unstemmed Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title_short Immunolocalization of Corticotropin-Releasing Hormone (CRH) and Its Receptors (CRHR1 and CRHR2) in Human Endometrial Carcinoma: CRHR1 as a Potent Prognostic Factor
title_sort immunolocalization of corticotropin-releasing hormone (crh) and its receptors (crhr1 and crhr2) in human endometrial carcinoma: crhr1 as a potent prognostic factor
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215916/
https://www.ncbi.nlm.nih.gov/pubmed/25254562
http://dx.doi.org/10.1097/IGC.0000000000000269
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