Whole Exome Sequencing Identifies Novel Genes for Fetal Hemoglobin Response to Hydroxyurea in Children with Sickle Cell Anemia

Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug response variation is heritable. To test the hypothesis...

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Detalles Bibliográficos
Autores principales: Sheehan, Vivien A., Crosby, Jacy R., Sabo, Aniko, Mortier, Nicole A., Howard, Thad A., Muzny, Donna M., Dugan-Perez, Shannon, Aygun, Banu, Nottage, Kerri A., Boerwinkle, Eric, Gibbs, Richard A., Ware, Russell E., Flanagan, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215999/
https://www.ncbi.nlm.nih.gov/pubmed/25360671
http://dx.doi.org/10.1371/journal.pone.0110740

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