Cargando…
Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7%
OBJECTIVE: To investigate whether fluctuations between the fasting and 2-h postload glucose ([2-hPBG]-fasting blood glucose [FBG]) states are associated with glomerular hyperfiltration (GHF) in middle-aged and elderly Chinese patients with newly diagnosed diabetes. DESIGN AND METHODS: In this study,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216006/ https://www.ncbi.nlm.nih.gov/pubmed/25360521 http://dx.doi.org/10.1371/journal.pone.0111173 |
_version_ | 1782342191629205504 |
---|---|
author | Hou, Xinguo Wang, Chuan Wang, Shaoyuan Yang, Weifang Ma, Zeqiang Wang, Yulian Li, Chengqiao Li, Mei Zhang, Xiuping Zhao, Xiangmin Sun, Yu Song, Jun Lin, Peng Liang, Kai Gong, Lei Wang, Meijian Liu, Fuqiang Li, Wenjuan Yan, Fei Yang, Junpeng Wang, Lingshu Tian, Meng Liu, Jidong Zhao, Ruxing Chen, Shihong Chen, Li |
author_facet | Hou, Xinguo Wang, Chuan Wang, Shaoyuan Yang, Weifang Ma, Zeqiang Wang, Yulian Li, Chengqiao Li, Mei Zhang, Xiuping Zhao, Xiangmin Sun, Yu Song, Jun Lin, Peng Liang, Kai Gong, Lei Wang, Meijian Liu, Fuqiang Li, Wenjuan Yan, Fei Yang, Junpeng Wang, Lingshu Tian, Meng Liu, Jidong Zhao, Ruxing Chen, Shihong Chen, Li |
author_sort | Hou, Xinguo |
collection | PubMed |
description | OBJECTIVE: To investigate whether fluctuations between the fasting and 2-h postload glucose ([2-hPBG]-fasting blood glucose [FBG]) states are associated with glomerular hyperfiltration (GHF) in middle-aged and elderly Chinese patients with newly diagnosed diabetes. DESIGN AND METHODS: In this study, we included 679 newly diagnosed diabetes patients who were ≥40 years old. All the subjects were divided into two groups; those with HbA1c<7% and ≥7%. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate the glomerular filtration rate (GFR). GHF was defined as an eGFR ≥ the 90th percentile. First, a multiple linear regression analysis was used to estimate the association of 2-hPBG-FBG with eGFR. Then, a generalized additive model was used to explore the possible nonlinear relationship between 2-hPBG-FBG and eGFR. Next, the 2-hPBG-FBG values were divided into four groups as follows: 0–36, 36–72, 72–108 and ≥108 mg/dl. Finally, a multiple logistic regression analysis was used to investigate the association of 2-hPBG-FBG with the risk of GHF. RESULTS: For the group with HbA1c<7%, the eGFR and the percentage of GHF were significantly higher compared with the group with HbA1c≥7%. After adjusting for age, gender, body mass index (BMI), systolic blood pressure (BP), diastolic BP, fasting insulin, cholesterol, triglycerides, smoking, drinking and glycated hemoglobin (HbA1c), 2-hPBG-FBG was significantly associated with increased eGFR and an increased risk of GHF (the GHF risk increased by 64.9% for every 36.0 mg/dl [2.0 mmol/L] 2-hPBG-FBG increase) only in those patients with HbA1c<7%. Additionally, 2-hPBG-FBG and eGFR showed a nonlinear association (P<0.001). CONCLUSIONS: Increased fluctuations between the fasting and 2-h postload glucose states are closely associated with increased eGFR and an increased risk of GHF in newly diagnosed diabetes patients with HbA1c<7%. |
format | Online Article Text |
id | pubmed-4216006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42160062014-11-05 Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% Hou, Xinguo Wang, Chuan Wang, Shaoyuan Yang, Weifang Ma, Zeqiang Wang, Yulian Li, Chengqiao Li, Mei Zhang, Xiuping Zhao, Xiangmin Sun, Yu Song, Jun Lin, Peng Liang, Kai Gong, Lei Wang, Meijian Liu, Fuqiang Li, Wenjuan Yan, Fei Yang, Junpeng Wang, Lingshu Tian, Meng Liu, Jidong Zhao, Ruxing Chen, Shihong Chen, Li PLoS One Research Article OBJECTIVE: To investigate whether fluctuations between the fasting and 2-h postload glucose ([2-hPBG]-fasting blood glucose [FBG]) states are associated with glomerular hyperfiltration (GHF) in middle-aged and elderly Chinese patients with newly diagnosed diabetes. DESIGN AND METHODS: In this study, we included 679 newly diagnosed diabetes patients who were ≥40 years old. All the subjects were divided into two groups; those with HbA1c<7% and ≥7%. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate the glomerular filtration rate (GFR). GHF was defined as an eGFR ≥ the 90th percentile. First, a multiple linear regression analysis was used to estimate the association of 2-hPBG-FBG with eGFR. Then, a generalized additive model was used to explore the possible nonlinear relationship between 2-hPBG-FBG and eGFR. Next, the 2-hPBG-FBG values were divided into four groups as follows: 0–36, 36–72, 72–108 and ≥108 mg/dl. Finally, a multiple logistic regression analysis was used to investigate the association of 2-hPBG-FBG with the risk of GHF. RESULTS: For the group with HbA1c<7%, the eGFR and the percentage of GHF were significantly higher compared with the group with HbA1c≥7%. After adjusting for age, gender, body mass index (BMI), systolic blood pressure (BP), diastolic BP, fasting insulin, cholesterol, triglycerides, smoking, drinking and glycated hemoglobin (HbA1c), 2-hPBG-FBG was significantly associated with increased eGFR and an increased risk of GHF (the GHF risk increased by 64.9% for every 36.0 mg/dl [2.0 mmol/L] 2-hPBG-FBG increase) only in those patients with HbA1c<7%. Additionally, 2-hPBG-FBG and eGFR showed a nonlinear association (P<0.001). CONCLUSIONS: Increased fluctuations between the fasting and 2-h postload glucose states are closely associated with increased eGFR and an increased risk of GHF in newly diagnosed diabetes patients with HbA1c<7%. Public Library of Science 2014-10-31 /pmc/articles/PMC4216006/ /pubmed/25360521 http://dx.doi.org/10.1371/journal.pone.0111173 Text en © 2014 Hou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hou, Xinguo Wang, Chuan Wang, Shaoyuan Yang, Weifang Ma, Zeqiang Wang, Yulian Li, Chengqiao Li, Mei Zhang, Xiuping Zhao, Xiangmin Sun, Yu Song, Jun Lin, Peng Liang, Kai Gong, Lei Wang, Meijian Liu, Fuqiang Li, Wenjuan Yan, Fei Yang, Junpeng Wang, Lingshu Tian, Meng Liu, Jidong Zhao, Ruxing Chen, Shihong Chen, Li Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title | Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title_full | Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title_fullStr | Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title_full_unstemmed | Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title_short | Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7% |
title_sort | fluctuation between fasting and 2-h postload glucose state is associated with glomerular hyperfiltration in newly diagnosed diabetes patients with hba1c < 7% |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216006/ https://www.ncbi.nlm.nih.gov/pubmed/25360521 http://dx.doi.org/10.1371/journal.pone.0111173 |
work_keys_str_mv | AT houxinguo fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT wangchuan fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT wangshaoyuan fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT yangweifang fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT mazeqiang fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT wangyulian fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT lichengqiao fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT limei fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT zhangxiuping fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT zhaoxiangmin fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT sunyu fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT songjun fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT linpeng fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT liangkai fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT gonglei fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT wangmeijian fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT liufuqiang fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT liwenjuan fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT yanfei fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT yangjunpeng fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT wanglingshu fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT tianmeng fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT liujidong fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT zhaoruxing fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT chenshihong fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 AT chenli fluctuationbetweenfastingand2hpostloadglucosestateisassociatedwithglomerularhyperfiltrationinnewlydiagnoseddiabetespatientswithhba1c7 |