Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats

Neutrophil activation is associated with the development of organ injury after trauma–hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma–hemorrhagic shock-induced...

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Autores principales: Hwang, Tsong-Long, Shen, Hsin-I, Liu, Fu-Chao, Tsai, Hsin-I, Wu, Yang-Chang, Chang, Fang-Rong, Yu, Huang-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216084/
https://www.ncbi.nlm.nih.gov/pubmed/25360589
http://dx.doi.org/10.1371/journal.pone.0111365
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author Hwang, Tsong-Long
Shen, Hsin-I
Liu, Fu-Chao
Tsai, Hsin-I
Wu, Yang-Chang
Chang, Fang-Rong
Yu, Huang-Ping
author_facet Hwang, Tsong-Long
Shen, Hsin-I
Liu, Fu-Chao
Tsai, Hsin-I
Wu, Yang-Chang
Chang, Fang-Rong
Yu, Huang-Ping
author_sort Hwang, Tsong-Long
collection PubMed
description Neutrophil activation is associated with the development of organ injury after trauma–hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma–hemorrhagic shock-induced hepatic and lung injuries in rats. In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma–hemorrhagic shock. In conclusion, ursolic acid, a bioactive natural compound, inhibits superoxide anion generation and elastase release in human neutrophils and ameliorates trauma–hemorrhagic shock-induced organ injury in rats.
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spelling pubmed-42160842014-11-05 Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats Hwang, Tsong-Long Shen, Hsin-I Liu, Fu-Chao Tsai, Hsin-I Wu, Yang-Chang Chang, Fang-Rong Yu, Huang-Ping PLoS One Research Article Neutrophil activation is associated with the development of organ injury after trauma–hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma–hemorrhagic shock-induced hepatic and lung injuries in rats. In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma–hemorrhagic shock. In conclusion, ursolic acid, a bioactive natural compound, inhibits superoxide anion generation and elastase release in human neutrophils and ameliorates trauma–hemorrhagic shock-induced organ injury in rats. Public Library of Science 2014-10-31 /pmc/articles/PMC4216084/ /pubmed/25360589 http://dx.doi.org/10.1371/journal.pone.0111365 Text en © 2014 Hwang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hwang, Tsong-Long
Shen, Hsin-I
Liu, Fu-Chao
Tsai, Hsin-I
Wu, Yang-Chang
Chang, Fang-Rong
Yu, Huang-Ping
Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title_full Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title_fullStr Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title_full_unstemmed Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title_short Ursolic Acid Inhibits Superoxide Production in Activated Neutrophils and Attenuates Trauma-Hemorrhage Shock-Induced Organ Injury in Rats
title_sort ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216084/
https://www.ncbi.nlm.nih.gov/pubmed/25360589
http://dx.doi.org/10.1371/journal.pone.0111365
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