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Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis
[Image: see text] The 19-transmembrane γ-secretase complex generates the amyloid β-peptide of Alzheimer’s disease by intramembrane proteolysis of the β-amyloid precursor protein. This complex is comprised of presenilin, Aph1, nicastrin, and Pen-2. The exact function and mechanism of the highly conse...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216188/ https://www.ncbi.nlm.nih.gov/pubmed/24941111 http://dx.doi.org/10.1021/bi500489j |