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Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas
[Image: see text] A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216194/ https://www.ncbi.nlm.nih.gov/pubmed/24971635 http://dx.doi.org/10.1021/ol501531q |
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author | Ernst, Johannes B. Tay, Nicholas E. S. Jui, Nathan T. Buchwald, Stephen L. |
author_facet | Ernst, Johannes B. Tay, Nicholas E. S. Jui, Nathan T. Buchwald, Stephen L. |
author_sort | Ernst, Johannes B. |
collection | PubMed |
description | [Image: see text] A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C–N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials. |
format | Online Article Text |
id | pubmed-4216194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42161942015-06-27 Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas Ernst, Johannes B. Tay, Nicholas E. S. Jui, Nathan T. Buchwald, Stephen L. Org Lett [Image: see text] A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C–N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials. American Chemical Society 2014-06-27 2014-07-18 /pmc/articles/PMC4216194/ /pubmed/24971635 http://dx.doi.org/10.1021/ol501531q Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
spellingShingle | Ernst, Johannes B. Tay, Nicholas E. S. Jui, Nathan T. Buchwald, Stephen L. Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas |
title | Regioselective Synthesis of Benzimidazolones via Cascade
C–N Coupling of Monosubstituted Ureas |
title_full | Regioselective Synthesis of Benzimidazolones via Cascade
C–N Coupling of Monosubstituted Ureas |
title_fullStr | Regioselective Synthesis of Benzimidazolones via Cascade
C–N Coupling of Monosubstituted Ureas |
title_full_unstemmed | Regioselective Synthesis of Benzimidazolones via Cascade
C–N Coupling of Monosubstituted Ureas |
title_short | Regioselective Synthesis of Benzimidazolones via Cascade
C–N Coupling of Monosubstituted Ureas |
title_sort | regioselective synthesis of benzimidazolones via cascade
c–n coupling of monosubstituted ureas |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216194/ https://www.ncbi.nlm.nih.gov/pubmed/24971635 http://dx.doi.org/10.1021/ol501531q |
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