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Pyroglutamylated Amyloid-β Peptide Reverses Cross β-Sheets by a Prion-Like Mechanism

[Image: see text] The amyloid hypothesis causatively relates the fibrillar deposits of amyloid β peptide (Aβ) to Alzheimer’s disease (AD). More recent data, however, identify the soluble oligomers as the major cytotoxic entities. Pyroglutamylated Aβ (pE-Aβ) is present in AD brains and exerts augment...

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Detalles Bibliográficos
Autores principales:	Matos, Jason O., Goldblatt, Greg, Jeon, Jaekyun, Chen, Bo, Tatulian, Suren A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216196/ https://www.ncbi.nlm.nih.gov/pubmed/24802697 http://dx.doi.org/10.1021/jp412743s

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