Synthesis and Evaluation of Bisbenzylidenedioxotetrahydrothiopranones as Activators of Endoplasmic Reticulum (ER) Stress Signaling Pathways and Apoptotic Cell Death in Acute Promyelocytic Leukemic Cells

[Image: see text] Curcumin is known to trigger ER-stress induced cell death of acute promyelocytic leukemic (APL) cells by intercepting the degradation of nuclear co-repressor (N-CoR) protein which has a key role in the pathogenesis of APL. Replacing the heptadienedione moiety of curcumin with a mon...

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Detalles Bibliográficos
Autores principales: Tan, Kheng-Lin, Ali, Azhar, Du, Yuhong, Fu, Haian, Jin, Hai-Xiao, Chin, Tan-Min, Khan, Matiullah, Go, Mei-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216202/
https://www.ncbi.nlm.nih.gov/pubmed/24960549
http://dx.doi.org/10.1021/jm401352a

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