Designing Allosteric Inhibitors of Factor XIa. Lessons from the Interactions of Sulfated Pentagalloylglucopyranosides

[Image: see text] We recently introduced sulfated pentagalloylglucopyranoside (SPGG) as an allosteric inhibitor of factor XIa (FXIa) (Al-Horani et al., J. Med Chem.2013, 56, 867–87823316863). To better understand the SPGG–FXIa interaction, we utilized eight SPGG variants and a range of biochemical t...

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Detalles Bibliográficos
Autores principales: Al-Horani, Rami A., Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216218/
https://www.ncbi.nlm.nih.gov/pubmed/24844380
http://dx.doi.org/10.1021/jm500311e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216218/
https://www.ncbi.nlm.nih.gov/pubmed/24844380
http://dx.doi.org/10.1021/jm500311e

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