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Synthetic Reactions with Rare Taccalonolides Reveal the Value of C-22,23 Epoxidation for Microtubule Stabilizing Potency

[Image: see text] The taccalonolides are microtubule stabilizers isolated from plants of the genus Tacca. Taccalonolide AF is 231 times more potent than the major metabolite taccalonolide A and differs only by the oxidation of the C-22,23 double bond in A to an epoxy group in AF. In the current stud...

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Detalles Bibliográficos
Autores principales:	Peng, Jiangnan, Risinger, April L., Li, Jing, Mooberry, Susan L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216226/ https://www.ncbi.nlm.nih.gov/pubmed/24959756 http://dx.doi.org/10.1021/jm500619j

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