Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer

Everolimus is an inhibitor of mammalian target of rapamycin with anti-tumour activity. While everolimus is known to cause drug-induced pneumonitis, it is rarely associated with Pneumocystis jirovecii pneumonia (PJP). We report a patient on everolimus therapy for metastatic breast cancer that develop...

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Autores principales: Kuik, Kelvin Teck-Hong, Trubiano, Jason, Worth, Leon J., Harun, Nur-shirin, Steinfort, Daniel, Johnson, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216328/
https://www.ncbi.nlm.nih.gov/pubmed/25379397
http://dx.doi.org/10.1016/j.mmcr.2014.08.007
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author Kuik, Kelvin Teck-Hong
Trubiano, Jason
Worth, Leon J.
Harun, Nur-shirin
Steinfort, Daniel
Johnson, Douglas
author_facet Kuik, Kelvin Teck-Hong
Trubiano, Jason
Worth, Leon J.
Harun, Nur-shirin
Steinfort, Daniel
Johnson, Douglas
author_sort Kuik, Kelvin Teck-Hong
collection PubMed
description Everolimus is an inhibitor of mammalian target of rapamycin with anti-tumour activity. While everolimus is known to cause drug-induced pneumonitis, it is rarely associated with Pneumocystis jirovecii pneumonia (PJP). We report a patient on everolimus therapy for metastatic breast cancer that developed PJP. Diagnosis was based on clinical features and a quantitative polymerase chain reaction for P. jirovecii DNA. Clinicians should consider PJP as a potential cause of pulmonary infiltrates in patients treated with everolimus.
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spelling pubmed-42163282014-11-06 Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer Kuik, Kelvin Teck-Hong Trubiano, Jason Worth, Leon J. Harun, Nur-shirin Steinfort, Daniel Johnson, Douglas Med Mycol Case Rep Article Everolimus is an inhibitor of mammalian target of rapamycin with anti-tumour activity. While everolimus is known to cause drug-induced pneumonitis, it is rarely associated with Pneumocystis jirovecii pneumonia (PJP). We report a patient on everolimus therapy for metastatic breast cancer that developed PJP. Diagnosis was based on clinical features and a quantitative polymerase chain reaction for P. jirovecii DNA. Clinicians should consider PJP as a potential cause of pulmonary infiltrates in patients treated with everolimus. Elsevier 2014-09-16 /pmc/articles/PMC4216328/ /pubmed/25379397 http://dx.doi.org/10.1016/j.mmcr.2014.08.007 Text en © 2014 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Kuik, Kelvin Teck-Hong
Trubiano, Jason
Worth, Leon J.
Harun, Nur-shirin
Steinfort, Daniel
Johnson, Douglas
Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title_full Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title_fullStr Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title_full_unstemmed Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title_short Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
title_sort pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216328/
https://www.ncbi.nlm.nih.gov/pubmed/25379397
http://dx.doi.org/10.1016/j.mmcr.2014.08.007
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