Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)

Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytoki...

Descripción completa

Detalles Bibliográficos
Autores principales: Trigo, Fernanda M.B., Luizon, Marcelo R., Dutra, Hélio S., Maiolino, Ângelo, Nucci, Márcio, Simões, Belinda P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216334/
https://www.ncbi.nlm.nih.gov/pubmed/25379407
http://dx.doi.org/10.1016/j.lrr.2014.05.002
_version_ 1782342241798324224
author Trigo, Fernanda M.B.
Luizon, Marcelo R.
Dutra, Hélio S.
Maiolino, Ângelo
Nucci, Márcio
Simões, Belinda P.
author_facet Trigo, Fernanda M.B.
Luizon, Marcelo R.
Dutra, Hélio S.
Maiolino, Ângelo
Nucci, Márcio
Simões, Belinda P.
author_sort Trigo, Fernanda M.B.
collection PubMed
description Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytokine genes may alter expression levels and affect IR. We performed interaction analysis of IL-6 (−174G/C) and TNF-α (−308G/A) polymorphisms with infection susceptibility in 148 patients classified accordingly to infection status and found an interaction when compared groups with and without bacteremia (p=0.0380). The interaction may be more important than single effects for the IR associated with the infection susceptibility in ASCT.
format Online
Article
Text
id pubmed-4216334
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-42163342014-11-06 Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT) Trigo, Fernanda M.B. Luizon, Marcelo R. Dutra, Hélio S. Maiolino, Ângelo Nucci, Márcio Simões, Belinda P. Leuk Res Rep Case Report Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytokine genes may alter expression levels and affect IR. We performed interaction analysis of IL-6 (−174G/C) and TNF-α (−308G/A) polymorphisms with infection susceptibility in 148 patients classified accordingly to infection status and found an interaction when compared groups with and without bacteremia (p=0.0380). The interaction may be more important than single effects for the IR associated with the infection susceptibility in ASCT. Elsevier 2014-09-01 /pmc/articles/PMC4216334/ /pubmed/25379407 http://dx.doi.org/10.1016/j.lrr.2014.05.002 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Case Report
Trigo, Fernanda M.B.
Luizon, Marcelo R.
Dutra, Hélio S.
Maiolino, Ângelo
Nucci, Márcio
Simões, Belinda P.
Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title_full Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title_fullStr Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title_full_unstemmed Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title_short Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT)
title_sort interaction between il-6 and tnf-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (asct)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216334/
https://www.ncbi.nlm.nih.gov/pubmed/25379407
http://dx.doi.org/10.1016/j.lrr.2014.05.002
work_keys_str_mv AT trigofernandamb interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct
AT luizonmarcelor interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct
AT dutrahelios interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct
AT maiolinoangelo interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct
AT nuccimarcio interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct
AT simoesbelindap interactionbetweenil6andtnfagenotypesassociatedwithbacteremiainmultiplemyelomapatientssubmittedtoautologousstemcelltransplantationasct

Ejemplares similares