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A randomized trial of preoperative oral carbohydrates in abdominal surgery
BACKGROUND: Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. METHODS: A random...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216365/ https://www.ncbi.nlm.nih.gov/pubmed/25364300 http://dx.doi.org/10.1186/1471-2253-14-93 |
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author | Sada, Fatos Krasniqi, Avdyl Hamza, Astrit Gecaj-Gashi, Agreta Bicaj, Besnik Kavaja, Floren |
author_facet | Sada, Fatos Krasniqi, Avdyl Hamza, Astrit Gecaj-Gashi, Agreta Bicaj, Besnik Kavaja, Floren |
author_sort | Sada, Fatos |
collection | PubMed |
description | BACKGROUND: Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. METHODS: A randomized, double blind, prospective study of patients undergoing open colorectal operations (CR) and open cholecyctectomy (CH) was conducted. Patients were divided into three groups: study, placebo, and control. Visual analogue scale (VAS) scores for seven parameters (thirst, hunger, anxiety, mouth dryness, nausea, weakness and sleep quality) were recorded and compared for two different time periods (up to 24 h postoperatively and from 36 to 48 h postoperatively). The Simplified Acute Physiology Score changes (SAPS)-II between the three groups were also studied. RESULTS: There were 142 patients American Society of Anesthesiology (ASA) I or II enrolled in the study (CR = 71 and CH = 71). There were no significant differences in postoperative SAPS-II scores or lengths of hospital stay (LOS) between the groups. However, in CR patients, the degree of thirst was partially improved by drinking CRLDs (P = 0.027). In CH patients, on the other hand, feelings of thirst, hunger, mouth dryness, nausea and weakness showed significant improvement (P < 0.05). CONCLUSION: Oral administration of carbohydrate-rich liquid drinks (CRLDs) improves the well-being in patients undergoing CH, but the effect is less evident in patients undergoing CR. No significant improvements were seen in clinical status or in length of hospital stay in either group. TRIAL REGISTRATION: ANZCTR.org.au: ACTRN12614000995673 (registered on 16/09/2014). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2253-14-93) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4216365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42163652014-11-02 A randomized trial of preoperative oral carbohydrates in abdominal surgery Sada, Fatos Krasniqi, Avdyl Hamza, Astrit Gecaj-Gashi, Agreta Bicaj, Besnik Kavaja, Floren BMC Anesthesiol Research Article BACKGROUND: Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. METHODS: A randomized, double blind, prospective study of patients undergoing open colorectal operations (CR) and open cholecyctectomy (CH) was conducted. Patients were divided into three groups: study, placebo, and control. Visual analogue scale (VAS) scores for seven parameters (thirst, hunger, anxiety, mouth dryness, nausea, weakness and sleep quality) were recorded and compared for two different time periods (up to 24 h postoperatively and from 36 to 48 h postoperatively). The Simplified Acute Physiology Score changes (SAPS)-II between the three groups were also studied. RESULTS: There were 142 patients American Society of Anesthesiology (ASA) I or II enrolled in the study (CR = 71 and CH = 71). There were no significant differences in postoperative SAPS-II scores or lengths of hospital stay (LOS) between the groups. However, in CR patients, the degree of thirst was partially improved by drinking CRLDs (P = 0.027). In CH patients, on the other hand, feelings of thirst, hunger, mouth dryness, nausea and weakness showed significant improvement (P < 0.05). CONCLUSION: Oral administration of carbohydrate-rich liquid drinks (CRLDs) improves the well-being in patients undergoing CH, but the effect is less evident in patients undergoing CR. No significant improvements were seen in clinical status or in length of hospital stay in either group. TRIAL REGISTRATION: ANZCTR.org.au: ACTRN12614000995673 (registered on 16/09/2014). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2253-14-93) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-17 /pmc/articles/PMC4216365/ /pubmed/25364300 http://dx.doi.org/10.1186/1471-2253-14-93 Text en © Sada et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sada, Fatos Krasniqi, Avdyl Hamza, Astrit Gecaj-Gashi, Agreta Bicaj, Besnik Kavaja, Floren A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title | A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title_full | A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title_fullStr | A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title_full_unstemmed | A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title_short | A randomized trial of preoperative oral carbohydrates in abdominal surgery |
title_sort | randomized trial of preoperative oral carbohydrates in abdominal surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216365/ https://www.ncbi.nlm.nih.gov/pubmed/25364300 http://dx.doi.org/10.1186/1471-2253-14-93 |
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