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The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells

The anti-apoptotic proteins Bcl-X(L) and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations. This prompted us to test the BH3-mimetic compound ABT-737 for...

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Detalles Bibliográficos
Autores principales:	Baev, Denis V., Krawczyk, Janusz, O׳Dwyer, Michael, Szegezdi, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216386/ https://www.ncbi.nlm.nih.gov/pubmed/25379408 http://dx.doi.org/10.1016/j.lrr.2014.06.001

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