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Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo
The elaboration of anterior–posterior (A–P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216468/ https://www.ncbi.nlm.nih.gov/pubmed/25349454 http://dx.doi.org/10.1098/rstb.2013.0546 |
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author | Stower, Matthew J. Srinivas, Shankar |
author_facet | Stower, Matthew J. Srinivas, Shankar |
author_sort | Stower, Matthew J. |
collection | PubMed |
description | The elaboration of anterior–posterior (A–P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epithelial cells, the anterior visceral endoderm (AVE). The AVE is a signalling centre that is responsible for several important patterning events during early development, including specifying the orientation of the A–P axis and the position of the heart with respect to the brain. AVE cells undergo a characteristic stereotypical migration which is crucial to their functions. |
format | Online Article Text |
id | pubmed-4216468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42164682014-12-05 Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo Stower, Matthew J. Srinivas, Shankar Philos Trans R Soc Lond B Biol Sci Articles The elaboration of anterior–posterior (A–P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epithelial cells, the anterior visceral endoderm (AVE). The AVE is a signalling centre that is responsible for several important patterning events during early development, including specifying the orientation of the A–P axis and the position of the heart with respect to the brain. AVE cells undergo a characteristic stereotypical migration which is crucial to their functions. The Royal Society 2014-12-05 /pmc/articles/PMC4216468/ /pubmed/25349454 http://dx.doi.org/10.1098/rstb.2013.0546 Text en http://creativecommons.org/licenses/by/3.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Stower, Matthew J. Srinivas, Shankar Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title | Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title_full | Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title_fullStr | Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title_full_unstemmed | Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title_short | Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
title_sort | heading forwards: anterior visceral endoderm migration in patterning the mouse embryo |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216468/ https://www.ncbi.nlm.nih.gov/pubmed/25349454 http://dx.doi.org/10.1098/rstb.2013.0546 |
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