Cargando…

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied. Generally, planar polycyclic molecules such as polycyclic aromatic hydrocarbons, stilbenoids, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jiawang, Sridhar, Jayalakshmi, Foroozesh, Maryam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216474/ https://www.ncbi.nlm.nih.gov/pubmed/24287985 http://dx.doi.org/10.3390/molecules181214470

Ejemplares similares

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies
por: Sridhar, Jayalakshmi, et al.
Publicado: (2012)

Coumarins and P450s, Studies Reported to-Date
por: Foroozesh, Maryam, et al.
Publicado: (2019)

Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1
por: Goyal, Navneet, et al.
Publicado: (2014)

Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date
por: Sridhar, Jayalakshmi, et al.
Publicado: (2017)

Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors
por: Dutkiewicz, Zbigniew, et al.
Publicado: (2018)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450
por: Otey, Christopher R, et al.
Publicado: (2006)

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
por: Mukherjee, Goutam, et al.
Publicado: (2021)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine
por: Goyal, Navneet, et al.
Publicado: (2021)

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors
por: Akram, Muhammad, et al.
Publicado: (2017)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

The cytochrome P450 family in the parasitic nematode Haemonchus contortus
por: Laing, Roz, et al.
Publicado: (2015)

Structure and function of the cytochrome P450 peroxygenase enzymes
por: Munro, Andrew W., et al.
Publicado: (2018)

Structural Models for Cytochrome P450—Mediated Catalysis
por: Lewis, David F.V.
Publicado: (2003)

Molecular and Structural Evolution of Cytochrome P450 Aromatase
por: Di Nardo, Giovanna, et al.
Publicado: (2021)

Structural Insights on the Conversion of Cytochrome P450 to P420
por: Gable, Jessica A., et al.
Publicado: (2022)

Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis
por: Ishikawa, Noemia Kazue, et al.
Publicado: (2014)

Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors
por: Jackson, Klarissa D., et al.
Publicado: (2018)

Studies of the expression of the cytochrome P450IA, P450IIB, and P450IIC gene family in extrahepatic and hepatic tissues.
por: Friedberg, T, et al.
Publicado: (1990)

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
por: Zhang, Hai-Feng, et al.
Publicado: (2016)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli
por: Quehl, Paul, et al.
Publicado: (2016)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Robust Profiling of Cytochrome P450s (P450ome) in Notable Aspergillus spp.
por: Dauda, Wadzani Palnam, et al.
Publicado: (2022)

Enzyme Activity of Natural Products on Cytochrome P450
por: Zuo, Hua-Li, et al.
Publicado: (2022)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Intronic polymorphisms of cytochromes P450
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2010)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

Cytochromes P450, Oxygen, and Evolution
por: Lewis, David F.V., et al.
Publicado: (2001)

Relationships among ergot alkaloids, cytochrome P450 activity, and beef steer growth
por: Rosenkrans, Charles F., et al.
Publicado: (2015)

Fungal Cytochrome P450 Monooxygenases: Their Distribution, Structure, Functions, Family Expansion, and Evolutionary Origin
por: Chen, Wanping, et al.
Publicado: (2014)

Prediction and analysis of the modular structure of cytochrome P450 monooxygenases
por: Sirim, Demet, et al.
Publicado: (2010)

Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes
por: Ghosh, Sumit
Publicado: (2017)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Epoxidation Activities of Human Cytochromes P450c17 and P450c21
por: Yoshimoto, Francis K., et al.
Publicado: (2014)

Computational Prediction of Inhibitors and Inducers of the Major Isoforms of Cytochrome P450
por: Rudik, Anastassia, et al.
Publicado: (2022)

Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
por: Shin, Jiyoung, et al.
Publicado: (2018)

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs
por: Liu, Kang‐Cheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f1idtgi83jopprrkci1gkuibnl