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The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus 1
BACKGROUND: Herpes Simplex Virus 1 (HSV-1) resistance to drugs and the side effects of drugs have drawn the attention of investigators to herbal plants. OBJECTIVES: The main aim of the current research was to investigate the effects of Glycyrrhiza glabra (liquorice root) on HSV-1. One of the objecti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216581/ https://www.ncbi.nlm.nih.gov/pubmed/25368801 http://dx.doi.org/10.5812/jjm.11616 |
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author | Sabouri Ghannad, Masoud Mohammadi, Avid Safiallahy, Sohayla Faradmal, Javad Azizi, Mona Ahmadvand, Zohreh |
author_facet | Sabouri Ghannad, Masoud Mohammadi, Avid Safiallahy, Sohayla Faradmal, Javad Azizi, Mona Ahmadvand, Zohreh |
author_sort | Sabouri Ghannad, Masoud |
collection | PubMed |
description | BACKGROUND: Herpes Simplex Virus 1 (HSV-1) resistance to drugs and the side effects of drugs have drawn the attention of investigators to herbal plants. OBJECTIVES: The main aim of the current research was to investigate the effects of Glycyrrhiza glabra (liquorice root) on HSV-1. One of the objectives of the current research was to determine the efficacy and the effect of the elapsed incubation time of treating the Vero cells infected with HSV-1 by G. glabra. In addition, the effect of cells pretreatment with licorice root extract, preincubation of virus with licorice root extract, and the antiviral activity were assessed. PATIENTS AND METHODS: Vero cells were incubated after adding different concentrations of aqueous extracts of G. glabra. The cells were incubated during various time courses. Cytotoxicity assay, determining the 50% tissue culture infectious dose (TCID(50)), and incubation of HSV-1 with licorice root extract prior to viral infection were performed. RESULTS: Internal association among different experiment groups showed the significant difference in the efficacy of the extract with regard to incubation period between one and four hours, one and eight hours, four and 12 hours, and eight and 12 hours. Moreover, there was a significant difference with regard to efficacy among the pretreatment of cells with extract for two hours, incubation of virus with extract for one hour, incubation of virus with extract for two hours. CONCLUSIONS: G. glabra showed the characteristics of a novel antiviral medication; however, more in vitro experiments are needed to determine the antiherpetic activities of the G. glabra. |
format | Online Article Text |
id | pubmed-4216581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-42165812014-11-03 The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus 1 Sabouri Ghannad, Masoud Mohammadi, Avid Safiallahy, Sohayla Faradmal, Javad Azizi, Mona Ahmadvand, Zohreh Jundishapur J Microbiol Research Article BACKGROUND: Herpes Simplex Virus 1 (HSV-1) resistance to drugs and the side effects of drugs have drawn the attention of investigators to herbal plants. OBJECTIVES: The main aim of the current research was to investigate the effects of Glycyrrhiza glabra (liquorice root) on HSV-1. One of the objectives of the current research was to determine the efficacy and the effect of the elapsed incubation time of treating the Vero cells infected with HSV-1 by G. glabra. In addition, the effect of cells pretreatment with licorice root extract, preincubation of virus with licorice root extract, and the antiviral activity were assessed. PATIENTS AND METHODS: Vero cells were incubated after adding different concentrations of aqueous extracts of G. glabra. The cells were incubated during various time courses. Cytotoxicity assay, determining the 50% tissue culture infectious dose (TCID(50)), and incubation of HSV-1 with licorice root extract prior to viral infection were performed. RESULTS: Internal association among different experiment groups showed the significant difference in the efficacy of the extract with regard to incubation period between one and four hours, one and eight hours, four and 12 hours, and eight and 12 hours. Moreover, there was a significant difference with regard to efficacy among the pretreatment of cells with extract for two hours, incubation of virus with extract for one hour, incubation of virus with extract for two hours. CONCLUSIONS: G. glabra showed the characteristics of a novel antiviral medication; however, more in vitro experiments are needed to determine the antiherpetic activities of the G. glabra. Kowsar 2014-07-01 2014-07 /pmc/articles/PMC4216581/ /pubmed/25368801 http://dx.doi.org/10.5812/jjm.11616 Text en Copyright © 2014, Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sabouri Ghannad, Masoud Mohammadi, Avid Safiallahy, Sohayla Faradmal, Javad Azizi, Mona Ahmadvand, Zohreh The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus 1 |
title | The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus
1 |
title_full | The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus
1 |
title_fullStr | The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus
1 |
title_full_unstemmed | The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus
1 |
title_short | The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus
1 |
title_sort | effect of aqueous extract of glycyrrhiza glabra on herpes simplex virus
1 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216581/ https://www.ncbi.nlm.nih.gov/pubmed/25368801 http://dx.doi.org/10.5812/jjm.11616 |
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