MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

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p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood. We previously reported that 8-oxoguanine (8-oxoG) accumulation in nuclear DNA (nDNA) and mitochondrial DNA triggers two distinct caspase-indepen...

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Detalles Bibliográficos
Autores principales: Oka, S, Leon, J, Tsuchimoto, D, Sakumi, K, Nakabeppu, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216901/
https://www.ncbi.nlm.nih.gov/pubmed/25310643
http://dx.doi.org/10.1038/oncsis.2014.35
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