Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

Mutational heterogeneity must be taken into account when reconstructing evolutionary histories, calibrating molecular clocks, and predicting links between genes and disease. Selective pressures and various DNA transactions have been invoked to explain the heterogeneous distribution of genetic variat...

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Detalles Bibliográficos
Autores principales: Lujan, Scott A., Clausen, Anders R., Clark, Alan B., MacAlpine, Heather K., MacAlpine, David M., Malc, Ewa P., Mieczkowski, Piotr A., Burkholder, Adam B., Fargo, David C., Gordenin, Dmitry A., Kunkel, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216917/
https://www.ncbi.nlm.nih.gov/pubmed/25217194
http://dx.doi.org/10.1101/gr.178335.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216917/
https://www.ncbi.nlm.nih.gov/pubmed/25217194
http://dx.doi.org/10.1101/gr.178335.114

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