TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

The evolution of cancer genomes within a single tumor creates mixed cell populations with divergent somatic mutational landscapes. Inference of tumor subpopulations has been disproportionately focused on the assessment of somatic point mutations, whereas computational methods targeting evolutionary...

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Detalles Bibliográficos
Autores principales: Ha, Gavin, Roth, Andrew, Khattra, Jaswinder, Ho, Julie, Yap, Damian, Prentice, Leah M., Melnyk, Nataliya, McPherson, Andrew, Bashashati, Ali, Laks, Emma, Biele, Justina, Ding, Jiarui, Le, Alan, Rosner, Jamie, Shumansky, Karey, Marra, Marco A., Gilks, C. Blake, Huntsman, David G., McAlpine, Jessica N., Aparicio, Samuel, Shah, Sohrab P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216928/
https://www.ncbi.nlm.nih.gov/pubmed/25060187
http://dx.doi.org/10.1101/gr.180281.114

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