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Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction
Gene knockdown using micro RNA (miRNA)-based vector constructs is likely to become a prominent gene therapy approach. It was the aim of this study to improve the efficiency of gene knockdown through optimizing the structure of miRNA mimics. Knockdown of two target genes was analyzed: CCR5 and green...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217082/ https://www.ncbi.nlm.nih.gov/pubmed/25350582 http://dx.doi.org/10.1038/mtna.2014.58 |