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Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex
During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (P(OUT)) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable confor...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217140/ https://www.ncbi.nlm.nih.gov/pubmed/25417110 http://dx.doi.org/10.1016/j.cell.2014.10.001 |