Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

Proneurogenic compounds have recently shown promise in some mouse models of Alzheimer's pathology. Antagonists at Group II metabotropic glutamate receptors (Group II mGluR: mGlu(2), mGlu(3)) are reported to stimulate neurogenesis. Agonists at those receptors trigger γ-secretase-inhibitor-sensit...

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Detalles Bibliográficos
Autores principales: Kim, S H, Steele, J W, Lee, S W, Clemenson, G D, Carter, T A, Treuner, K, Gadient, R, Wedel, P, Glabe, C, Barlow, C, Ehrlich, M E, Gage, F H, Gandy, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217144/
https://www.ncbi.nlm.nih.gov/pubmed/25113378
http://dx.doi.org/10.1038/mp.2014.87

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