NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton

AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigat...

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Detalles Bibliográficos
Autores principales: Ha, Van Thai, Beak, Heung Soo, Kim, Eunji, Baek, Kwang-Soo, Hossen, Muhammad Jahangir, Yang, Woo Seok, Kim, Yong, Kim, Jun Ho, Yang, Sungjae, Kim, Jeong-Hwan, Joo, Yung Hyup, Lee, Chang Seok, Choi, Joonho, Shin, Hong-Ju, Hong, Sungyoul, Shin, Song Seok, Cho, Jae Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217328/
https://www.ncbi.nlm.nih.gov/pubmed/25386046
http://dx.doi.org/10.1155/2014/354843

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