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Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation

Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates...

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Detalles Bibliográficos
Autores principales: Zhu, Haitao, Yu, Liang, He, Yayi, Wang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217338/
https://www.ncbi.nlm.nih.gov/pubmed/25389531
http://dx.doi.org/10.1155/2014/785948
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author Zhu, Haitao
Yu, Liang
He, Yayi
Wang, Bo
author_facet Zhu, Haitao
Yu, Liang
He, Yayi
Wang, Bo
author_sort Zhu, Haitao
collection PubMed
description Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation.
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spelling pubmed-42173382014-11-11 Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation Zhu, Haitao Yu, Liang He, Yayi Wang, Bo J Diabetes Res Review Article Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation. Hindawi Publishing Corporation 2014 2014-10-20 /pmc/articles/PMC4217338/ /pubmed/25389531 http://dx.doi.org/10.1155/2014/785948 Text en Copyright © 2014 Haitao Zhu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhu, Haitao
Yu, Liang
He, Yayi
Wang, Bo
Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title_full Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title_fullStr Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title_full_unstemmed Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title_short Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
title_sort nonhuman primate models of type 1 diabetes mellitus for islet transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217338/
https://www.ncbi.nlm.nih.gov/pubmed/25389531
http://dx.doi.org/10.1155/2014/785948
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