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Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation
Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217338/ https://www.ncbi.nlm.nih.gov/pubmed/25389531 http://dx.doi.org/10.1155/2014/785948 |
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author | Zhu, Haitao Yu, Liang He, Yayi Wang, Bo |
author_facet | Zhu, Haitao Yu, Liang He, Yayi Wang, Bo |
author_sort | Zhu, Haitao |
collection | PubMed |
description | Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation. |
format | Online Article Text |
id | pubmed-4217338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42173382014-11-11 Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation Zhu, Haitao Yu, Liang He, Yayi Wang, Bo J Diabetes Res Review Article Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation. Hindawi Publishing Corporation 2014 2014-10-20 /pmc/articles/PMC4217338/ /pubmed/25389531 http://dx.doi.org/10.1155/2014/785948 Text en Copyright © 2014 Haitao Zhu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Haitao Yu, Liang He, Yayi Wang, Bo Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title | Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title_full | Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title_fullStr | Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title_full_unstemmed | Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title_short | Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation |
title_sort | nonhuman primate models of type 1 diabetes mellitus for islet transplantation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217338/ https://www.ncbi.nlm.nih.gov/pubmed/25389531 http://dx.doi.org/10.1155/2014/785948 |
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