Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's Dementia

Introduction. Converging evidence suggests that PDE-4 (phosphodiesterase subtype 4) plays a crucial role in regulating cognition via the PDE-4-cAMP cascade signaling involving phosphorylated cAMP response element binding protein (CREB). Objective. The primary endpoint was to examine the neurocogniti...

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Detalles Bibliográficos
Autores principales: Chiu, Simon, Gericke, Nigel, Farina-Woodbury, Michel, Badmaev, Vladimir, Raheb, Hana, Terpstra, Kristen, Antongiorgi, Joalex, Bureau, Yves, Cernovsky, Zack, Hou, Jirui, Sanchez, Veronica, Williams, Marissa, Copen, John, Husni, Mariwan, Goble, Liz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217361/
https://www.ncbi.nlm.nih.gov/pubmed/25389443
http://dx.doi.org/10.1155/2014/682014

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