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The impact of microglial activation on blood-brain barrier in brain diseases

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs) together with neurons and glial cells, including microglia, forms the neurovascular unit (NVU). The crosstalk between these cells guarantees a proper environment for brain function. In this context, changes...

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Autores principales: da Fonseca, Anna Carolina Carvalho, Matias, Diana, Garcia, Celina, Amaral, Rackele, Geraldo, Luiz Henrique, Freitas, Catarina, Lima, Flavia Regina Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217497/
https://www.ncbi.nlm.nih.gov/pubmed/25404894
http://dx.doi.org/10.3389/fncel.2014.00362
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author da Fonseca, Anna Carolina Carvalho
Matias, Diana
Garcia, Celina
Amaral, Rackele
Geraldo, Luiz Henrique
Freitas, Catarina
Lima, Flavia Regina Souza
author_facet da Fonseca, Anna Carolina Carvalho
Matias, Diana
Garcia, Celina
Amaral, Rackele
Geraldo, Luiz Henrique
Freitas, Catarina
Lima, Flavia Regina Souza
author_sort da Fonseca, Anna Carolina Carvalho
collection PubMed
description The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs) together with neurons and glial cells, including microglia, forms the neurovascular unit (NVU). The crosstalk between these cells guarantees a proper environment for brain function. In this context, changes in the endothelium-microglia interactions are associated with a variety of inflammation-related diseases in brain, where BBB permeability is compromised. Increasing evidences indicate that activated microglia modulate expression of tight junctions, which are essential for BBB integrity and function. On the other hand, the endothelium can regulate the state of microglial activation. Here, we review recent advances that provide insights into interactions between the microglia and the vascular system in brain diseases such as infectious/inflammatory diseases, epilepsy, ischemic stroke and neurodegenerative disorders.
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spelling pubmed-42174972014-11-17 The impact of microglial activation on blood-brain barrier in brain diseases da Fonseca, Anna Carolina Carvalho Matias, Diana Garcia, Celina Amaral, Rackele Geraldo, Luiz Henrique Freitas, Catarina Lima, Flavia Regina Souza Front Cell Neurosci Neuroscience The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs) together with neurons and glial cells, including microglia, forms the neurovascular unit (NVU). The crosstalk between these cells guarantees a proper environment for brain function. In this context, changes in the endothelium-microglia interactions are associated with a variety of inflammation-related diseases in brain, where BBB permeability is compromised. Increasing evidences indicate that activated microglia modulate expression of tight junctions, which are essential for BBB integrity and function. On the other hand, the endothelium can regulate the state of microglial activation. Here, we review recent advances that provide insights into interactions between the microglia and the vascular system in brain diseases such as infectious/inflammatory diseases, epilepsy, ischemic stroke and neurodegenerative disorders. Frontiers Media S.A. 2014-11-03 /pmc/articles/PMC4217497/ /pubmed/25404894 http://dx.doi.org/10.3389/fncel.2014.00362 Text en Copyright © 2014 da Fonseca, Matias, Garcia, Amaral, Geraldo, Freitas and Lima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
da Fonseca, Anna Carolina Carvalho
Matias, Diana
Garcia, Celina
Amaral, Rackele
Geraldo, Luiz Henrique
Freitas, Catarina
Lima, Flavia Regina Souza
The impact of microglial activation on blood-brain barrier in brain diseases
title The impact of microglial activation on blood-brain barrier in brain diseases
title_full The impact of microglial activation on blood-brain barrier in brain diseases
title_fullStr The impact of microglial activation on blood-brain barrier in brain diseases
title_full_unstemmed The impact of microglial activation on blood-brain barrier in brain diseases
title_short The impact of microglial activation on blood-brain barrier in brain diseases
title_sort impact of microglial activation on blood-brain barrier in brain diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217497/
https://www.ncbi.nlm.nih.gov/pubmed/25404894
http://dx.doi.org/10.3389/fncel.2014.00362
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