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Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice

BACKGROUND: Metabolic disorders, caused by excessive calorie intake and low physical activity, are important cardiovascular risk factors. Rho-kinase, an effector protein of the small GTP-binding protein RhoA, is an important cardiovascular therapeutic target and its activity is increased in patients...

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Detalles Bibliográficos
Autores principales:	Noda, Kazuki, Nakajima, Sota, Godo, Shigeo, Saito, Hiroki, Ikeda, Shohei, Shimizu, Toru, Enkhjargal, Budbazar, Fukumoto, Yoshihiro, Tsukita, Sohei, Yamada, Tetsuya, Katagiri, Hideki, Shimokawa, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217731/ https://www.ncbi.nlm.nih.gov/pubmed/25365359 http://dx.doi.org/10.1371/journal.pone.0110446

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