Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness

Advanced glycation end-products (AGE) contribute to age-related connective tissue damage and functional deficit. The documented association between AGE formation on collagens and the correlated progressive stiffening of tissues has widely been presumed causative, despite the lack of mechanistic unde...

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Detalles Bibliográficos
Autores principales: Fessel, Gion, Li, Yufei, Diederich, Vincent, Guizar-Sicairos, Manuel, Schneider, Philipp, Sell, David R., Monnier, Vincent M., Snedeker, Jess G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217736/
https://www.ncbi.nlm.nih.gov/pubmed/25364829
http://dx.doi.org/10.1371/journal.pone.0110948

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