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Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes
Cancer metastasis is an invasive process that involves the transplantation of cells into new environments. Since human placentation is also invasive, hypotheses about a relationship between invasive placentation in eutherian mammals and metastasis have been proposed. The relationship between metasta...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217742/ https://www.ncbi.nlm.nih.gov/pubmed/25324490 http://dx.doi.org/10.1093/emph/eou022 |
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author | D'Souza, Alaric W. Wagner, Günter P. |
author_facet | D'Souza, Alaric W. Wagner, Günter P. |
author_sort | D'Souza, Alaric W. |
collection | PubMed |
description | Cancer metastasis is an invasive process that involves the transplantation of cells into new environments. Since human placentation is also invasive, hypotheses about a relationship between invasive placentation in eutherian mammals and metastasis have been proposed. The relationship between metastatic cancer and invasive placentation is usually presented in terms of antagonistic pleiotropy. According to this hypothesis, evolution of invasive placentation also established the mechanisms for cancer metastasis. Here, in contrast, we argue that the secondary evolution of less invasive placentation in some mammalian lineages may have resulted in positive pleiotropic effects on cancer survival by lowering malignancy rates. These positive pleiotropic effects would manifest themselves as resistance to cancer cell invasion. To provide a preliminary test of this proposal, we re-analyze data from Priester and Mantel (Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine. J Natl Cancer Inst 1971;47:1333-44) about malignancy rates in cows, horses, cats and dogs. From our analysis we found that equines and bovines, animals with less invasive placentation, have lower rates of metastatic cancer than felines and canines in skin and glandular epithelial cancers as well as connective tissue sarcomas. We conclude that a link between type of placentation and species-specific malignancy rates is more likely related to derived mechanisms that suppress invasion rather than different degrees of fetal placental aggressiveness. |
format | Online Article Text |
id | pubmed-4217742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42177422014-11-05 Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes D'Souza, Alaric W. Wagner, Günter P. Evol Med Public Health Review Cancer metastasis is an invasive process that involves the transplantation of cells into new environments. Since human placentation is also invasive, hypotheses about a relationship between invasive placentation in eutherian mammals and metastasis have been proposed. The relationship between metastatic cancer and invasive placentation is usually presented in terms of antagonistic pleiotropy. According to this hypothesis, evolution of invasive placentation also established the mechanisms for cancer metastasis. Here, in contrast, we argue that the secondary evolution of less invasive placentation in some mammalian lineages may have resulted in positive pleiotropic effects on cancer survival by lowering malignancy rates. These positive pleiotropic effects would manifest themselves as resistance to cancer cell invasion. To provide a preliminary test of this proposal, we re-analyze data from Priester and Mantel (Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine. J Natl Cancer Inst 1971;47:1333-44) about malignancy rates in cows, horses, cats and dogs. From our analysis we found that equines and bovines, animals with less invasive placentation, have lower rates of metastatic cancer than felines and canines in skin and glandular epithelial cancers as well as connective tissue sarcomas. We conclude that a link between type of placentation and species-specific malignancy rates is more likely related to derived mechanisms that suppress invasion rather than different degrees of fetal placental aggressiveness. Oxford University Press 2014-10-15 /pmc/articles/PMC4217742/ /pubmed/25324490 http://dx.doi.org/10.1093/emph/eou022 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review D'Souza, Alaric W. Wagner, Günter P. Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title | Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title_full | Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title_fullStr | Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title_full_unstemmed | Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title_short | Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes |
title_sort | malignant cancer and invasive placentation: a case for positive pleiotropy between endometrial and malignancy phenotypes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217742/ https://www.ncbi.nlm.nih.gov/pubmed/25324490 http://dx.doi.org/10.1093/emph/eou022 |
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