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Social, economic, and health impact of the respiratory syncytial virus: a systematic search

BACKGROUND: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different asp...

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Autores principales: Díez-Domingo, Javier, Pérez-Yarza, Eduardo G, Melero, José A, Sánchez-Luna, Manuel, Aguilar, María Dolores, Blasco, Antonio Javier, Alfaro, Noelia, Lázaro, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219051/
https://www.ncbi.nlm.nih.gov/pubmed/25358423
http://dx.doi.org/10.1186/s12879-014-0544-x
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author Díez-Domingo, Javier
Pérez-Yarza, Eduardo G
Melero, José A
Sánchez-Luna, Manuel
Aguilar, María Dolores
Blasco, Antonio Javier
Alfaro, Noelia
Lázaro, Pablo
author_facet Díez-Domingo, Javier
Pérez-Yarza, Eduardo G
Melero, José A
Sánchez-Luna, Manuel
Aguilar, María Dolores
Blasco, Antonio Javier
Alfaro, Noelia
Lázaro, Pablo
author_sort Díez-Domingo, Javier
collection PubMed
description BACKGROUND: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection. METHODS: A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included. RESULTS: The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments). CONCLUSIONS: We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0544-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-42190512014-11-05 Social, economic, and health impact of the respiratory syncytial virus: a systematic search Díez-Domingo, Javier Pérez-Yarza, Eduardo G Melero, José A Sánchez-Luna, Manuel Aguilar, María Dolores Blasco, Antonio Javier Alfaro, Noelia Lázaro, Pablo BMC Infect Dis Research Article BACKGROUND: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection. METHODS: A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included. RESULTS: The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments). CONCLUSIONS: We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0544-x) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-30 /pmc/articles/PMC4219051/ /pubmed/25358423 http://dx.doi.org/10.1186/s12879-014-0544-x Text en © Díez-Domingo et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Díez-Domingo, Javier
Pérez-Yarza, Eduardo G
Melero, José A
Sánchez-Luna, Manuel
Aguilar, María Dolores
Blasco, Antonio Javier
Alfaro, Noelia
Lázaro, Pablo
Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title_full Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title_fullStr Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title_full_unstemmed Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title_short Social, economic, and health impact of the respiratory syncytial virus: a systematic search
title_sort social, economic, and health impact of the respiratory syncytial virus: a systematic search
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219051/
https://www.ncbi.nlm.nih.gov/pubmed/25358423
http://dx.doi.org/10.1186/s12879-014-0544-x
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