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Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis

BACKGROUND: Novel molecules that specifically target human TNFα in rheumatoid arthritis pose problems for preclinical assessment of efficacy. In this study collagen antibody-induced arthritis (CAIA) has been induced in human TNFα transgenic mice to provide a novel model that has been optimised for t...

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Detalles Bibliográficos
Autores principales:	Moore, Adrian Richard, Allden, Sarah, Bourne, Tim, Denis, Maria C, Kranidioti, Ksanthi, Okoye, Remi, Sotsios, Yannis, Stencel, Zofia, Vugler, Alexander, Watt, Gillian, Shaw, Stevan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219128/ https://www.ncbi.nlm.nih.gov/pubmed/25344414 http://dx.doi.org/10.1186/s12967-014-0285-z

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