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Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study

Background and aims: Barrett’s esophagus (BE) and colorectal neoplasms share similar risk factors. Previous studies have shown variable prevalence of colon polyps in patients with BE. Our aims were to determine the prevalence and incidence of colon polyps in patients with BE, compared to those witho...

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Autores principales: Kumaravel, Arthi, Thota, Prashanthi N., Lee, Hyun-Ju, Gohel, Tushar, Kanadiya, Mehulkumar K., Lopez, Rocio, Sanaka, Madhusudhan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219145/
https://www.ncbi.nlm.nih.gov/pubmed/25085954
http://dx.doi.org/10.1093/gastro/gou050
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author Kumaravel, Arthi
Thota, Prashanthi N.
Lee, Hyun-Ju
Gohel, Tushar
Kanadiya, Mehulkumar K.
Lopez, Rocio
Sanaka, Madhusudhan R.
author_facet Kumaravel, Arthi
Thota, Prashanthi N.
Lee, Hyun-Ju
Gohel, Tushar
Kanadiya, Mehulkumar K.
Lopez, Rocio
Sanaka, Madhusudhan R.
author_sort Kumaravel, Arthi
collection PubMed
description Background and aims: Barrett’s esophagus (BE) and colorectal neoplasms share similar risk factors. Previous studies have shown variable prevalence of colon polyps in patients with BE. Our aims were to determine the prevalence and incidence of colon polyps in patients with BE, compared to those without BE. Methods: In this case-control study, the study group included patients, aged 50–75 years, with biopsy-proven BE, who underwent colonoscopy at Cleveland Clinic from January 2002 to December 2011. The control group consisted of age- and sex-matched patients who underwent colonoscopy and also an endoscopy with no evidence of BE during the same time period. Exclusion criteria for both groups were family- or personal previous history of colon cancer or polyps, prior colonic resection, inflammatory bowel disease and familial polyposis syndromes. Patient demographics, comorbidities, medication use and endoscopic and colonoscopic details were collected, including biopsy results. Results: A total of 519 patients were included in the study; 173 patients with BE in the study group and 346 without BE in the control group. Mean age at index colonoscopy was 61 ± 8 years and 75% of patients were male. On index colonoscopy, patients with BE were more likely to have polyps than controls (45% vs 32%, respectively; P = 0.003). Patients underwent between one and five colonoscopies during the follow-up. On multivariate analysis—after adjusting for age, gender and diabetes—patients with BE were 80% more likely to have any type of polyp, and 50% more likely to have adenomas found during colonoscopy. Conclusions: Patients with BE had higher prevalence and incidence of colon polyps. This has important clinical implications for screening and surveillance in BE patients.
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spelling pubmed-42191452014-11-05 Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study Kumaravel, Arthi Thota, Prashanthi N. Lee, Hyun-Ju Gohel, Tushar Kanadiya, Mehulkumar K. Lopez, Rocio Sanaka, Madhusudhan R. Gastroenterol Rep (Oxf) Original Articles Background and aims: Barrett’s esophagus (BE) and colorectal neoplasms share similar risk factors. Previous studies have shown variable prevalence of colon polyps in patients with BE. Our aims were to determine the prevalence and incidence of colon polyps in patients with BE, compared to those without BE. Methods: In this case-control study, the study group included patients, aged 50–75 years, with biopsy-proven BE, who underwent colonoscopy at Cleveland Clinic from January 2002 to December 2011. The control group consisted of age- and sex-matched patients who underwent colonoscopy and also an endoscopy with no evidence of BE during the same time period. Exclusion criteria for both groups were family- or personal previous history of colon cancer or polyps, prior colonic resection, inflammatory bowel disease and familial polyposis syndromes. Patient demographics, comorbidities, medication use and endoscopic and colonoscopic details were collected, including biopsy results. Results: A total of 519 patients were included in the study; 173 patients with BE in the study group and 346 without BE in the control group. Mean age at index colonoscopy was 61 ± 8 years and 75% of patients were male. On index colonoscopy, patients with BE were more likely to have polyps than controls (45% vs 32%, respectively; P = 0.003). Patients underwent between one and five colonoscopies during the follow-up. On multivariate analysis—after adjusting for age, gender and diabetes—patients with BE were 80% more likely to have any type of polyp, and 50% more likely to have adenomas found during colonoscopy. Conclusions: Patients with BE had higher prevalence and incidence of colon polyps. This has important clinical implications for screening and surveillance in BE patients. Oxford University Press 2014-11 2014-07-31 /pmc/articles/PMC4219145/ /pubmed/25085954 http://dx.doi.org/10.1093/gastro/gou050 Text en © The Author(s) 2014. Published by Oxford University Press and the Digestive Science Publishing Co. Limited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kumaravel, Arthi
Thota, Prashanthi N.
Lee, Hyun-Ju
Gohel, Tushar
Kanadiya, Mehulkumar K.
Lopez, Rocio
Sanaka, Madhusudhan R.
Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title_full Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title_fullStr Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title_full_unstemmed Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title_short Higher prevalence of colon polyps in patients with Barrett’s esophagus: a case-control study
title_sort higher prevalence of colon polyps in patients with barrett’s esophagus: a case-control study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219145/
https://www.ncbi.nlm.nih.gov/pubmed/25085954
http://dx.doi.org/10.1093/gastro/gou050
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