High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame...

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Detalles Bibliográficos
Autores principales: Wang, Pu, Ma, Teng, Slipchenko, Mikhail N., Liang, Shanshan, Hui, Jie, Shung, K. Kirk, Roy, Sukesh, Sturek, Michael, Zhou, Qifa, Chen, Zhongping, Cheng, Ji-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219167/
https://www.ncbi.nlm.nih.gov/pubmed/25366991
http://dx.doi.org/10.1038/srep06889
Descripción
Sumario:Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO(3))(2)] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

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