High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame...

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Autores principales: Wang, Pu, Ma, Teng, Slipchenko, Mikhail N., Liang, Shanshan, Hui, Jie, Shung, K. Kirk, Roy, Sukesh, Sturek, Michael, Zhou, Qifa, Chen, Zhongping, Cheng, Ji-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219167/
https://www.ncbi.nlm.nih.gov/pubmed/25366991
http://dx.doi.org/10.1038/srep06889
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author Wang, Pu
Ma, Teng
Slipchenko, Mikhail N.
Liang, Shanshan
Hui, Jie
Shung, K. Kirk
Roy, Sukesh
Sturek, Michael
Zhou, Qifa
Chen, Zhongping
Cheng, Ji-Xin
author_facet Wang, Pu
Ma, Teng
Slipchenko, Mikhail N.
Liang, Shanshan
Hui, Jie
Shung, K. Kirk
Roy, Sukesh
Sturek, Michael
Zhou, Qifa
Chen, Zhongping
Cheng, Ji-Xin
author_sort Wang, Pu
collection PubMed
description Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO(3))(2)] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.
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spelling pubmed-42191672014-11-06 High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser Wang, Pu Ma, Teng Slipchenko, Mikhail N. Liang, Shanshan Hui, Jie Shung, K. Kirk Roy, Sukesh Sturek, Michael Zhou, Qifa Chen, Zhongping Cheng, Ji-Xin Sci Rep Article Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO(3))(2)] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting. Nature Publishing Group 2014-11-04 /pmc/articles/PMC4219167/ /pubmed/25366991 http://dx.doi.org/10.1038/srep06889 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Pu
Ma, Teng
Slipchenko, Mikhail N.
Liang, Shanshan
Hui, Jie
Shung, K. Kirk
Roy, Sukesh
Sturek, Michael
Zhou, Qifa
Chen, Zhongping
Cheng, Ji-Xin
High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title_full High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title_fullStr High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title_full_unstemmed High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title_short High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser
title_sort high-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-khz barium nitrite raman laser
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219167/
https://www.ncbi.nlm.nih.gov/pubmed/25366991
http://dx.doi.org/10.1038/srep06889
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